Multiclass screening of > 200 pharmaceutical and other residues in aquatic foods by ultrahigh-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry
文献类型： 外文期刊
作者： Kong, Cong 1 ; Wang, Yang 1 ; Huang, Yuanfei 1 ; Yu, Huijuan 3 ;
作者机构： 1.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Key Lab East China Sea Fishery Resources Exploita, Minist Agr, Shanghai 200090, Peoples R China
2.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China
3.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Key Lab Ocean & Polar Fisheries, Minist Agr, Shanghai 200090, Peoples R China
关键词： Veterinary drug; Aquatic food; Screening; Orbitrap; Pesticide; Contaminant residue
期刊名称：ANALYTICAL AND BIOANALYTICAL CHEMISTRY （ 影响因子：4.142； 五年影响因子：3.863 ）
ISSN： 1618-2642
年卷期： 2018 年 410 卷 22 期
页码：
收录情况： SCI
摘要： A quick screening method of more than 200 pharmaceutical and other residues in aquatic foods based on ultrahigh-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry (UHPLC-Q/Orbitrap MS) was established. In this method, after the addition of 200 mu L of 1 M EDTA-Na-2, 2 g of each sample homogenate was extracted successively with 10 mL of acetonitrile and 10 mL of ethyl acetate. The extracts were combined, dried under nitrogen flow, and redissolved in 0.1% formic acid in acetonitrile/water (4:6, v/v) for analysis. The prepared samples were analyzed by UHPLC- Q/Orbitrap MS system in Full MS/ddMS(2) (full-scan data-dependent MS/MS) mode. Compound identification was performed through comparison of the sample data with the database for standard chemicals, including the retention time, precursor ion, product ions, and isotope pattern for all 206 compounds. Five different aquatic food matrices (carp, shrimp, crab, eel, and mussel) spiked with the analytes at 1, 10, and 50 ng/g were evaluated to assess recoveries, precision, matrix effects, stability, and detection limits using the method. UHPLC analyses required 25 min, and 178-200 analytes met identification criteria at 50 ng/g depending on the matrix. Furthermore, practical application of this method for real samples displayed strong screening capability.
- 相关文献
作者其他论文 更多>>
-
One step cleanup of 160 pesticides and veterinary drugs in aquatic products using melamine-based automatic pressure filtration purification method combined with HPLC-MS/MS
作者：Zhou, Ruidong;Kong, Cong;Yang, Guangxin;Huang, Dongmei;Zhou, Ruidong;Wen, Yupeng;Huo, Wendi;Zhang, Chaoying;Sun, Huiwu;Liu, Huan;Li, Jincheng;Zhou, Ruidong;Wen, Yupeng;Huo, Wendi;Zhang, Chaoying;Sun, Huiwu;Liu, Huan;Li, Jincheng;Zhou, Ruidong;Wen, Yupeng;Huo, Wendi
关键词：Aquatic products; Pressure filtration cleanup column; Melamine sponge sorbent; Pesticides and veterinary drugs; Quantitative analysis; Health risk assessment
-
Rapid and selective detection of tetracyclic antibiotics in environmental water using Cu2+-doped hydrophilic imprinted melamine resin
作者：Gu, Lin;Ding, Shuhai;Zhang, Junyu;Yang, Guangxin;Ding, Shuhai;Zhang, Junyu;Yang, Guangxin;Wang, Longlong;Shen, Xiaoshen;Tian, Liangliang;Kong, Cong
关键词：Hydrophilic molecularly imprinted resin; Multiple adsorption mechanisms; Environmental samples; Tetracycline antibiotics
-
Development and validation of rapid screening of 192 veterinary drug residues in aquatic products using HPLC-HRMS coupled with QuEChERS
作者：Yang, Guangxin;Zhang, Junyu;Tang, Yunyu;Kong, Cong;Li, Siman;Wang, Shouying;Ding, Shuhai;Shen, Xiaosheng;Chi, Hai;Yang, Guangxin;Zhang, Junyu;Ding, Shuhai;Gu, Lin;Martin, Aka Alla
关键词：High resolution mass spectrometry; QuEChERS; Veterinary drug; Aquatic products; Screening
-
Determination of Free Glycidol and Total Free Monochloropropanediol in Fish and Krill Oil with Simple Aqueous Derivatization and High-Performance Liquid Chromatography-Tandem Mass Spectrometry
作者：Yang, Guangxin;Tang, Yunyu;Liu, Xiaoxia;Wang, Longlong;Shen, Xiaosheng;Kong, Cong;Fan, Chengqi;Liu, Xiaoxia;Wang, Longlong;Qin, Lixia;Li, Dan;Zhai, Wenlei;Fodjo, Essy Kouadio
关键词：monochloropropanediol; glycidol; p-(dimethylamino)phenol; krill oil; fish oil; demulsification
-
Research progress on metabolites of nitrofurazone in aquatic products
作者：Yang, Guangxin;Ding, Shuhai;Zhang, Junyu;Kong, Cong;Yang, Guangxin;Ding, Shuhai;Zhang, Junyu;Gu, Lin;Zhai, Wenlei
关键词：Nitrofurazone; Semcarbazide; Detection methods; Aquatic crustacean; Potential metabolites
-
Determination of earthy-musty odors in tap water by gas chromatography-mass spectrometry with silica solid-phase extraction
作者：Tian, Liangliang;Huang, Dongmei;Shi, Yongfu;Kong, Cong;Wang, Yuan;Tian, Liangliang;Shi, Yongfu;Wang, Yuan;Qu, Xin;Huang, Dongmei;Kong, Cong
关键词：n-Hexane; Silica; Earthy-musty; Tap water; Gas chromatography-mass spectrometry (GC-MS)
-
Development, validation, and implementation of an ultratrace analysis method for the determination of moenomycin A, in aquatic animal products
作者：Tang, Yunyu;Yang, Guangxin;Huang, Dongmei;Zhang, Xuan;Li, Siman;Shi, Yongfu;Kong, Cong;Ma, Yingqing;Zhang, Weiyi;Zhai, Wenlei;Fodjo, Essy Kouadio
关键词：Moenomycin A; Aquatic animal products; HPLC-MS/MS; Drug residues; Dispersive solid-phase extraction; Validation
