Bayesian population pharmacokinetic modeling of florfenicol in pigs after intravenous and intramuscular administration
文献类型： 外文期刊
作者： Liu, Zhichang 1 ; Rong, Ting 1 ; Zeng, Dongping 2 ; Shen, Xiangguang 2 ; Ma, Xianyong 1 ; Zeng, Zhenling 2 ;
作者机构： 1.Guangdong Acad Agr Sci, Key Lab Anim Nutr & Feed Sci South China, State Key Lab Livestock & Poultry Breeding,Inst A, Guangdong Publ Lab Anim Breeding & Nutr,Guangdong, Guangzhou, Guangdong, Peoples R China
2.South China Agr Univ, Guangdong Prov Key Lab Vet Pharmaceut Dev & Safet, Coll Vet Med, Guangzhou 510640, Guangdong, Peoples R China
关键词： Bayesian; florfenicol; Markov chain Monte Carlo; population pharmacokinetic; WinBUGS
期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）
ISSN： 0140-7783
年卷期： 2018 年 41 卷 5 期
页码：
收录情况： SCI
摘要： Bayesian population pharmacokinetic models of florfenicol in healthy pigs were developed based on retrospective data in pigs either via intravenous (i.v.) or intramuscular (i.m.) administration. Following i.v. administration, the disposition of florfenicol was best described by a two-compartment open model with the typical values of half-life at phase (t(1/2)), half-life at phase (t(1/2)), total body clearance (Cl), and volume of distribution (V-d) were 0.132 +/- 0.0289, 2.78 +/- 0.166hr, 0.215 +/- 0.0102, and 0.841 +/- 0.0289Lkg(-1), respectively. The disposition of florfenicol after i.m. administration was best described by a one-compartment open model. The typical values of maximum concentration of drug in serum (C-max), elimination half-life (t(1/2Kel)), Cl, and Volume (V) were 5.52 +/- 0.605g/ml, 9.96 +/- 1.12hr, 0.228 +/- 0.0154Lhr(-1)kg(-1), and 3.28 +/- 0.402L/kg, respectively. The between-subject variabilities of all the parameters after i.m. administration were between 25.1%-92.1%. Florfenicol was well absorbed (94.1%) after i.m. administration. According to Monte Carlo simulation, 8.5 and 6mg/kg were adequate to exert 90% bactericidal effect against Actinobacillus pleuropneumoniae after i.v. and i.m. administration.
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