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Sodium Butyrate Improves High-Concentrate-Diet-Induced Impairment of Runninal Epithelium Barrier Function in Goats

文献类型： 外文期刊

作者： Zhang, Kai 1 ; Meng, Meijuan 1 ; Gao, Lipeng 1 ; Tu, Yuanlu 1 ; Bai, Yunfeng 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Circular Agr Res Ctr, Nanjing 210014, Jiangsu, Peoples R China

2.Minist Agr, Key Lab Crop & Livestock Integrated Farming, Nanjing 210014, Jiangsu, Peoples R China

关键词： goat; subacute rumen acidosis; rumen epithelium; sodium butyrate; tight junction proteins

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2018 年 66 卷 33 期

页码：

收录情况： SCI

摘要： We investigated the effect of sodium butyrate feeding on the disruption of ruminal epithelium barrier function in goats fed a high-concentrate diet. A total of 18 male Boer goats (live weight of 31.75 +/- 1.35 kg, aged 1 year) were randomly assigned to three groups, which were fed a low-concentrate diet (LC), a high-concentrate diet (HC), or a high-concentrate diet with 1% sodium butyrate by weight (SH) for 9 weeks. We found that the pH of rumen fluid in the SH and LC groups was higher than that in the HC group. The activity of protein kinase C (PKC) kinase in the rumen epithelium was higher in the HC group than that in the LC and SH groups. The mRNA expression and phosphorylated protein levels of mitogen-activated protein kinases (MAPKs) in the rumen epithelium were lower in the SH and LC groups than those in the HC group. The DNA methylation rate of occludin was higher in the HC group than that in the SH and LC groups. The mRNA and protein expression of claudin-1, claudin-4, occludin, and zona occludin-1 was greater in the SH and LC groups than that in the HC group. In addition, sodium butyrate mitigated damage to the rumen epithelium caused by the HC diet. Together, our results suggest that the supply of sodium butyrate reverses the damage of rumen epithelium tight junction by inhibiting PKC and MAPK signaling pathways and is protective to the rumen epithelium during subacute rumen acidosis.

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