Genome-wide analysis of H3K36me3 and its regulations to cancer-related genes expression in human cell lines
文献类型： 外文期刊
作者： Zhang, Lu-Qiang 1 ; Li, Qian-Zhong 1 ; Jin, Wen 1 ; Zuo, Yongchun 1 ; Guo, Shu-Chun 1 ;
作者机构： 1.Inner Mongolia Univ, Sch Phys Sci & Technol, Lab Theoret Biophys, Hohhot 010021, Peoples R China
2.Inner Mongolia Univ, Coll Life Sci, Res Ctr Lab Anim Sci, Hohhot 010021, Peoples R China
3.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010021, Peoples R China
4.235 West Daxue Rd, Hohhot, Inner Mongolia, Peoples R China
关键词： H3K36me3; Histone modifications; Oncogenes; Tumor-suppressor genes
期刊名称：BIOSYSTEMS （ 影响因子：1.973； 五年影响因子：2.063 ）
ISSN： 0303-2647
年卷期： 2018 年 171 卷
页码：
收录情况： SCI
摘要： H3K36me3 is a histone modification known to mark active genes. To further understand the effects of H3K36me3 on gene expression levels, we develop predictive models to compute the correlation between the binding signal of H3K36me3 in each bin and the gene expression levels. We find that the bins with stronger H3K36me3 averaged-binding signals present higher correlative strengths with the expression levels of gene. And the higher correlative strengths appear in the downstream regions of the transcription start site. Moreover, we systematically compare the predictive abilities of 11 histone modifications to gene expression levels. The results show that H3K36me3 achieves a higher predictive ability than other modifications, and the higher predictive ability is robust across different mammalian cells and gene groups. Finally, in contrast to the two normal cell lines, our analysis finds that the predictive abilities of H3K36me3 are enhanced in 10 of the 13 bins for oncogenes and are decreased in 10 of 16 bins for tumor-suppressor genes in the cancer cell.
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