High-throughput measurements of ciprofloxacin, clomipramine and fexofenadine hydrochlorides with an 8-channel electrical titrator
文献类型： 外文期刊
作者： Zhang, Xuzhi 1 ; Yang, Qianqian 1 ; Zhang, Xuchang 2 ; Wang, Pingping 3 ; Hao, Zhihui 3 ; Zhao, Jun 1 ; Qu, Keming 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao Natl Lab Marine Sci & Technol, Qingdao 266071, Peoples R China
2.Longgang Dist Peoples Hosp, Dept Hematol, Shenzhen 518172, Peoples R China
3.Qingdao Agr Univ, Sch Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China
关键词： Eight-channel electrical titrator; Ciprofloxacin hydrochloride; Clomipramine hydrochloride; Fexofenadine hydrochloride; High throughput measurement; Pharmaceutical analysis
期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：6.779； 五年影响因子：4.558 ）
ISSN： 1001-8417
年卷期： 2018 年 29 卷 9 期
页码：
收录情况： SCI
摘要： High-throughput measurements of ciprofloxacin, clomipramine and fexofenadine hydrochlorides were performed by employing an automatic 8-channel electrical titrator. Silver nitrate (AgNO3) and sodium tetraphenylborate (NaTPB) were used as titrants. When AgNO3 was used for measuring the drugs in pure form, recoveries were 97.6%-102.0% with RSD values <= 1.0%; for measuring them in pharmaceutical formulations, recoveries were 96.6%-99.1% with RSD values <= 1.0%. Batch samples of eight could be measured simultaneously and maximally 30 measurements per minute could be completed. When NaTPB was used for measuring the drugs in pure form, the recoveries were 96.8%-102.6% with RSD values <= 0.8%; for measuring them in pharmaceutical formulations, the recoveries were 97.5%-102.7% with RSD values <= 0.9%. For all analyses, no auxiliary devices or chemicals were needed and there was no requirement for changing or cleaning working electrodes between measurements. The efficiency, accuracy and precision of the proposed method make it an alternative for routine quality control analyses. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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