文献类型： 外文期刊
作者： Mahjub, Reza 1 ; Jatana, Sukhdeep 1 ; Lee, Suen Ern 1 ; Qin, Zhu 1 ; Pauli, Griffin 1 ; Soleimani, Meysam 4 ; Madadi, 1 ;
作者机构： 1.Univ British Columbia, Fac Pharmaceut Sci, Vancouver Campus,5519-2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada
2.Hamadan Univ Med Sci, Sch Pharm, Dept Pharmaceut, Hamadan, Iran
3.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing 210014, Jiangsu, Peoples R China
4.Hamadan Univ Med Sci, Sch Pharm, Dept Pharmacognosy & Pharmaceut Biotechnol, Hamadan, Iran
5.Hamadan Univ Med Sci, Sch Pharm, Dept Pharmacognosy & Pharmaceut Biotechnol, Hamad
关键词： Cancer Immunotherapy; Nanoparticles; Antigenic Peptides; Oligodeoxynucleotides; Immunomodulatory siRNA; Antigenic pDNA; Immune check point inhibitor
期刊名称：JOURNAL OF CONTROLLED RELEASE （ 影响因子：9.776； 五年影响因子：10.413 ）
ISSN： 0168-3659
年卷期： 2018 年 288 卷
页码：
收录情况： SCI
摘要： Cancer immunotherapy aimed at boosting cancer-specific immunoresponses to eradicate tumor cells has evolved as a new treatment modality. Nanoparticles incorporating antigens and immunomodulatory agents can activate immune cells and modulate the tumor microenvironment to enhance anti-tumor immunity. The nanotechnology approach has been demonstrated to be superior to standard formulations in in-vivo settings. In this article, we focus on recent advances made within the last 5 years in nanoparticle-based cancer immunotherapy, including peptide- and nucleic acid-based nanovaccines, nanomedicines containing an immunoadjuvant to activate antitumor immunity, nanoparticle delivery of immune checkpoint inhibitors and the combination of the above approaches. Encouraging results and new emerging nanotechnologies in drug delivery promise the continuous growth of this field and ultimately clinical translation of enhanced immunotherapy of cancer.
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