Oligopeptide derived from solid-state fermented cottonseed meal significantly affect the immunomodulatory in BALB/c mice treated with cyclophosphamide
文献类型： 外文期刊
作者： Liu, Jiancheng 1 ; Sun, Hong 2 ; Nie, Cunxi 1 ; Ge, Wenxia 1 ; Wang, Yongqiang 1 ; Zhang, Wenju 1 ;
作者机构： 1.Shihezi Univ, Coll Anim Sci & Technol, North St 4, Shihezi 832000, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou, Zhejiang, Peoples R China
关键词： Cottonseed meal; Solid-state fermentation; Oligopeptide; Cyclophosphamide; Immunomodulatory
期刊名称：FOOD SCIENCE AND BIOTECHNOLOGY （ 影响因子：2.391； 五年影响因子：2.108 ）
ISSN： 1226-7708
年卷期： 2018 年 27 卷 6 期
页码：
收录情况： SCI
摘要： In this study, the immunomodulatory activity of oligopeptide (CP) derived from solid-state fermented cottonseed meal were investigated in immunosuppressed BALB/c mice models by treatment with cyclophosphamide (CY). Results indicated that oligopeptide increased the thymus and spleen indices of CY-treated mice. The count of plague forming cells (PFC)and the content of half serum hemolysis (HC50) in immunosuppressive mice were restored to the normal level in CP-10 and CP-20 groups while the cytokines interleukin (IL)-2, IL-6, and tumor necrosis factor alpha (TNF-)were increased significantly in CP-20 group. Similar increasing the immunoglobulin of IgG and IgM content in the serum of CP-10 group were also observed. These findings indicated that oligopeptide derived from solid-state fermented cottonseed meal had a strong immune-enhancing activity as well as a protective effect against immunosuppression induced by cyclophosphamide in mice.
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