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Facile Three-Component Synthesis, Insecticidal and Antifungal Evaluation of Novel Dihydropyridine Derivatives

文献类型： 外文期刊

作者： Yang, Guan-Zhou 1 ; Shang, Xiao-Fei 1 ; Cheng, Pi-Le 1 ; Yin, Xiao-Dan 1 ; Zhu, Jia-Kai 1 ; Liu, Ying-Qian 1 ; Zhang, 1 ;

作者机构： 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China

2.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730000, Gansu, Peoples R China

3.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Haikou 571010, Hainan, Peoples R China

关键词： neonicotinoid; insecticide; fungicide; dihydropyridine derivatives; three-component reaction

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2018 年 23 卷 10 期

页码：

收录情况： SCI

摘要： In an attempt to find the neonicotinoid insecticides, twenty novel dihydropyridine derivatives were designed, "green" synthesized via one pot facile three-component reaction and evaluated for their bioactivities against Tetranychus cinnabarinus, Myzus persicae, Brevicoryne brassicae, Fusarium oxysporum f. sp. vasinfectum, Magnaporthe oryzae, Sclerotinia sclerotiorum and Botrytis cinereal. All of the tested compounds showed potent insecticidal activity, and some were much better in comparison with imidacloprid (IMI). Especially, compounds 3d (LC50: 0.011 mM) and 5c (LC50: 0.025 mM) were 12.2-and 5.4-fold more active than IMI (LC50: 0.135 mM) against T. cinnabarinus, respectively. Moreover, out of all the derivatives, compound 3d (LC50: 0.0015 mM) exhibited the strongest insecticidal activity against B. brassicae and compound 3i (LC50: 0.0007 mM) displayed the strongest insecticidal activity against M. persicae. Surprisingly, when the concentration of compound 4 was 50 mg/L, the inhibition rate against F. oxysporum and S. sclerotiorum reached 45.00% and 65.83%, respectively. The present work indicated that novel dihydropyridine derivatives could be used as potential lead compounds for developing neonicotinoid insecticides and agricultural fungicides.

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