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Antiproliferative Activity of Combined Biochanin A and Ginsenoside Rh-2 on MDA-MB-231 and MCF-7 Human Breast Cancer Cells

文献类型： 外文期刊

作者： Ren, Guixing 1 ; Shi, Zhenxing 2 ; Teng, Cong 3 ; Yao, Yang 3 ;

作者机构： 1.Chengdu Univ, Coll Pharm & Biol Engn, 1 Shilling Rd,Chenglo Ave, Chengdu 610106, Sichuan, Peoples R China

2.Univ Liege, Lab Biomass & Green Technol, Gembloux Agrobio Tech, Passage Deportes 2, B-5030 Gembloux, Belgium

3.Chinese Acad Agr Sci, Inst Crop Sci, 80 South Xueyuan Rd, Beijing 100081, Peoples R China

关键词： synergy; biochanin A; Rh-2; breast cancer; antiproliferative activity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2018 年 23 卷 11 期

页码：

收录情况： SCI

摘要： Breast cancer is the most frequently diagnosed cancer in women worldwide. The antiproliferative activities of biochanin A (BA) and ginsenoside Rh-2 were determined by evaluating their inhibitory effect on MDA-MB-231 human breast cancer cell proliferation. The combination of BA with Rh-2 was also assessed. In MDA cells, combination treatment led to a decrease in the EC50 values of BA and Rh-2 to 25.20 mu M and 22.75 mu M, respectively. In MCF-7 cells, the EC50 values of combined BA and Rh-2 decreased to 27.68 mu M and 25.41 mu M, respectively. BA combined with Rh-2 also improved the inhibition of MDA-MB-231 and MCF-7 cell migration and invasion compared to the individual compounds. Western blot analysis demonstrated upregulation in p-p53, p-p38, and p-ASK1 proteins while levels of TRAF2 were downregulated. These results suggest that BA combined with Rh-2 exhibits synergistic effects against MDA-MB-231 and MCF-7 cell proliferation.

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