您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Pharmacokinetics of Florfenicol in the Orange-spotted Grouper, Epinephelus coioides, Following Oral Administration in Warm Seawater

文献类型： 外文期刊

作者： Feng, Jing-Bin 1 ; Ruan, Hui-Ting 4 ; Chen, Hai-Gang 5 ; Luo, Jun-Zhi 4 ; Dong, Jun-De 1 ;

作者机构： 1.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol LMB, Guangzhou 510301, Guangdong, Peoples R China

2.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Appl Marine Biol Guangdong Prov LAMB, Guangzhou 510301, Guangdong, Peoples R China

3.Chinese Acad Sci, South China Sea Inst Oceanol, Trop Marine Biol Res Stn Hainan, Sanya 572000, Peoples R China

4.South China Agr Univ, Dept Aquaculture, Coll Anim Sci, Guangzhou 510640, Guangdong, Peoples R China

5.Chinese Acad Fishery Sci, South China Fi

关键词： absorption; distribution; elimination; florfenicol; grouper; pharmacokinetics

期刊名称：JOURNAL OF THE WORLD AQUACULTURE SOCIETY （ 影响因子：2.512； 五年影响因子：2.47 ）

ISSN： 0893-8849

年卷期： 2018 年 49 卷 6 期

页码：

收录情况： SCI

摘要： Pharmacokinetics of florfenicol were studied in the orange-spotted grouper, Epinephelus coioides, at 29.0 +/- 1.0 C following oral administration of 5 or 10 mg/kg. Rapid absorption occurred, with a T-max (time to reach the maximum concentration) of 2-12 h in plasma, muscle, skin, liver, bile, intestine, kidney, and gill. The absorption rate appeared to decrease with increasing dosage, according to the observed T-max in plasma, muscle, skin, liver, and kidney. The maximum concentration (C-max) in plasma was 6.04 +/- 1.11 and 13.01 +/- 6.18 mu g/mL at 5 and 10 mg/kg, respectively, and was lower than that in the intestine but higher than in the other six tissues. A similar absorption and availability was found between the two doses by comparison of the ratios of area under the concentration-time curve (AUC) and dose among the tissues. A relatively low distribution level occurred in extravascular tissues based on the AUC values, with the exception of bile and intestine. The shortest and longest elimination half-life (T-1/2 beta) occurred in plasma (8.51 and 9.34 h at 5 and 10 mg/kg) and bile (18.13 and 17.63 h at 5 and 10 mg/kg), respectively. The elimination rate from plasma, muscle, and kidney was more rapid at 5 than at 10 mg/kg, according to the T-1/2 beta; however, the opposite situation was observed in the remaining five tissues.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台