Testicular transcriptome alterations in zebrafish (Danio rerio) exposure to 17 beta-estradiol
文献类型： 外文期刊
作者： Zheng, Yao 1 ; Yuan, Julin 2 ; Meng, Shunlong 1 ; Chen, Jiazhang 1 ; Gu, Zhimin 2 ;
作者机构： 1.Nanjing Agr Univ, Wuxi Fishery Coll,Chinese Acad Fishery Sci, Minist Agr,Freshwater Fisheries Res Ctr,Lab Qual, Fishery Ecoenvironm Monitoring Ctr Lower Reaches, Wuxi 214081, Jiangsu, Peoples R China
2.Zhejiang Inst Freshwater Fisheries, Agr Minist Key Lab Hlth Freshwater Aquaculture, Key Lab Freshwater Aquaculture Genet & Breeding Z, Huzhou 313001, Peoples R China
3.Minist Agr, Key Lab Control Qual & Safety Aquat Prod, Beijing 100039, Peoples R China
关键词： 17 beta-estradiol; Testicular transcriptome; Sex differentiation; Follicular development; Ribosome biogenesis
期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）
ISSN： 0045-6535
年卷期： 2019 年 218 卷
页码：
收录情况： SCI
摘要： The hormone 17 beta-estradiol (E-2) can be found in rivers, effluents, and even drinking water. Researches have demonstrated that E(2 )affects various metabolic pathways through gene activation and may cause reproductive toxicity in fish. Therefore, the aim of this study was to evaluate E-2-induced toxicity via testicular transcriptome of zebrafish (Danio rerio) exposed to different concentrations (10 ng L-1, and 100 ng L-1)of E-2. A total of >600 significant differentially expressed genes (DEGs) were enriched among the three treatments. Short time-series expression miner analysis revealed five KEGG pathways including drug metabolism, other enzymes, calcium signaling pathway, ECM-receptor interaction, gap junction, and cell adhesion molecules. Twenty genes were selected to verify the accuracy of RNA-Seq. Other reported genes related to sex differentiation, development, energy metabolism, and other processes were found. One set of genes significantly increased/decreased/fluctuated over time, especially 12 h after E-2 exposure. Genes associated with ovaries (zp3c), and development (bmp15, gdf9, and sycp2l) were significantly upregulated with increasing E-2 concentration. E-2 and testosterone was significantly decreased by 10 (except for T) and 100 ng L-1 E-2 exposure at 12 h. The current study demonstrated that sex differentiation, development, energy metabolism, immunity, and ribosome biogenesis in male zebrafish were all significantly affected by 17 beta-estradiol exposure through transcriptional alterations. (C) 2018 Elsevier Ltd. All rights reserved.
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