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Combined effects of pentachlorophenol and its byproduct hexachlorobenzene on endocrine and reproduction in zebrafish

文献类型： 外文期刊

作者： Sun, Wen 1 ; Jia, Yali 1 ; Ding, Xisheng 1 ; Dai, Lili 2 ; Liu, Chunsheng 1 ; Wang, Jianghua 1 ; Zhao, Gaofeng 5 ; Zhou, 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Beijing, Peoples R China

3.Collaborat Innovat Ctr Efficient & Hlth Prod Fish, Changde 415000, Hunan, Peoples R China

4.Hubei Prov Engn Lab Pond Aquaculture, Wuhan, Hubei, Peoples R China

5.China Inst Water Resources & Hydropower Res, Beijing 100038, Peoples R China

关键词： PCP; HCB; Reproductive toxicity; Combined toxicity; Zebrafish; Endocrine disruption

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

ISSN： 0045-6535

年卷期： 2019 年 220 卷

页码：

收录情况： SCI

摘要： Pentachlorophenol (PCP) and its byproduct hexachlorobenze (HCB) are two co-existing persistent environmental chemicals, but their combined toxicity remains unclear. In this study, adult zebrafish were exposed to 5 (low dose) and 25 mu g.L-1 (high dose) of PCP, HCB or their combination for 21 days, and the impact on endocrine and reproduction was investigated. Results showed that combined exposure to 25 mu g.L-1 PCP and 25 mu g.L-1 HCB significantly increased the plasma estradiol (E2) and testosterone (T) levels, altered the expressions of genes along the hypothalamic-pituitary-gonadal-liver (HPGL) axis, inhibited gonadal development, and eventually lead to decreased egg production of F0 zebrafish as well as inhibited development of F1 eggs/larvae. Compared to the combined exposure of high doses, significantly lower levels of plasma E2 and T were observed for either the high PCP or high HCB alone exposure, indicating a synergistic effect of the two chemicals on endocrine disruption after combination. Furthermore, the high PCP alone exposure inhibited the gonadal development in both the males and females, while the HCB alone exposure did not. Comparison of exposure effects indicated a greater decrease of mature gametes levels and egg production in the high combined group when compared to the high HCB alone group, but no significant difference was observed between the high combined group and the high PCP alone group. Taken together, the results suggested that combined exposure to PCP and HCB may synergistically affect endocrine of zebrafish, and result in reproduction impairments, with PCP being the primary contributor. (C) 2018 Published by Elsevier Ltd.

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