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Diversity and evolution of cytochromes P450 in stramenopiles

文献类型： 外文期刊

作者： Teng, Linhong 1 ; Fan, Xiao 1 ; Nelson, David R. 3 ; Han, Wentao 1 ; Zhang, Xiaowen 1 ; Xu, Dong 1 ; Renault, Hugues 4 ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

2.Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Peoples R China

3.Univ Tennessee, Hlth Sci Ctr, Dept Microbiol Immunol & Biochem, 858 Madison Ave Suite G01, Memphis, TN 38163 USA

4.Univ Strasbourg, CNRS, Inst Plant Mol Biol, F-67084 Strasbourg, France

5.Sorbonne Univ, CNRS, SBR, Integrat Biol Marine Models LB

关键词： Cytochrome P450; Comparative genomics; Molecular evolution; Stramenopiles

期刊名称：PLANTA （ 影响因子：4.116； 五年影响因子：4.316 ）

ISSN： 0032-0935

年卷期： 2019 年 249 卷 3 期

页码：

收录情况： SCI

摘要： Main conclusionComparative genomic analysis of cytochromes P450 revealed high diversification and dynamic changes in stramenopiles, associated with transcriptional responsiveness to various environmental stimuli.Comparative genomic and molecular evolution approaches were used to characterize cytochromes P450 (P450) diversity in stramenopiles. Phylogenetic analysis pointed to a high diversity of P450 in stramenopiles and identified three major clans. The CYP51 and CYP97 clans were present in brown algae, diatoms and Nannochloropsis gaditana, whereas the CYP5014 clan mainly includes oomycetes. Gene gain and loss patterns revealed that six CYP familiesCYP51, CYP97, CYP5160, CYP5021, CYP5022, and CYP5165predated the split of brown algae and diatoms. After they diverged, diatoms gained more CYP families, especially in the cold-adapted species Fragilariopsis cylindrus, in which eight new CYP families were found. Selection analysis revealed that the expanded CYP51 family in the brown alga Cladosiphon okamuranus exhibited a more relaxed selection constraint compared with those of other brown algae and diatoms. Our RNA-seq data further evidenced that most of P450s in Saccharina japonica are highly expressed in large sporophytes, which could potentially promote the large kelp formation in this developmental stage. A survey of Ectocarpus siliculosus and diatom transcriptomes showed that many P450s are responsive to stress, nutrient limitation or light quality, suggesting pivotal roles in detoxification or metabolic processes under adverse environmental conditions. The information provided in this study will be helpful in designing functional experiments and interpreting P450 roles in this particular lineage.

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