Immunotoxicity of Perfluorooctanoic Acid to the Marine Bivalve Species Ruditapes philippinarum
文献类型： 外文期刊
作者： Li, Fengling 1 ; Liu, Zhiyu 1 ; Yao, Lin 1 ; Jiang, Yanhua 1 ; Qu, Meng 1 ; Yu, Yongxing 1 ; Gong, Xiuqiong 1 ; Tan, Zhijun 1 ; Li, Zhaojie 5 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Testing & Evaluat Aquat Prod Safety & Qua, Minist Agr & Rural Affairs, Qingdao, Peoples R China
2.Shanghai Ocean Univ, Coll Marine Sci, Shanghai, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Qingdao, Peoples R China
4.Qingdao Agr Univ, Coll Food Sci & Engn, Qingdao, Peoples R China
5.Ocean Univ China, Coll Marine Life Sci, Qingdao, Peoples R China
关键词： Immunotoxicity; PFOA; Ruditapes philippinarum; Biomarker; Integrated biomarker response
期刊名称：ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY （ 影响因子：4.218； 五年影响因子：4.615 ）
ISSN： 0730-7268
年卷期： 2022 年 41 卷 2 期
页码：
收录情况： SCI
摘要： Polyfluorinated alkylated substances are recognized as an important class of pollutants in marine environments. Bivalves are good model organisms for evaluating the toxicity of pollutants and monitoring marine environments. In the present study, immunotoxicity of perfluorooctanoic acid (PFOA) was investigated by measuring biomarkers of the immune profile of Ruditapes philippinarum. In bivalves, hemocytes are an important component of the immune system. Thus, hemocyte proliferation, phagocytosis, cell viability, and immune enzyme activities, which have been applied as marine pollution bioindicators, were identified and observed for changes after exposure to PFOA in R. philippinarum. Based on the integrated biomarker responses method, we selected five biomarkers to evaluate PFOA risk at the multibiomarker level. In addition, the histopathological alterations of hemocytes in bivalves were used as indexes of the response to environmental stress. The subcellular structure of the hemocytes in R. philippinarum changed significantly with PFOA exposure, including hemocyte and nucleus morphological changes, organelle dissolution, cytomembrane and karyotheca swelling, and cytoplasm vacuolization. The present study verifies PFOA immunotoxicity to R. philippinarum at different levels and the integrated assessment of stress levels caused by PFOA in marine environment. Our results will provide new insights into evaluating adverse effects of PFOA and monitoring marine ecosystem. Environ Toxicol Chem 2022;00:1-11. (c) 2021 SETAC
- 相关文献
作者其他论文 更多>>
-
Effect of myosin-kappa carrageenan pickering emulsions on the quality of bighead carp surimi gels
作者：Ren, Zhongyang;Huang, Xianglan;Shi, Linfan;Yang, Shen;Jin, Ritian;Lin, Rong;Zhang, Yucang;Weng, Wuyin;Zhao, Yongqiang;Liu, Shuji;Liu, Zhiyu;Zhao, Yongqiang
关键词：Kappa carrageenan; Myosin; Pickering emulsions; Aristichthys nobilis; Surimi
-
Metabolic transformation of paralytic shellfish toxins in the mussel Mytilus galloprovincialis under different exposure modes
作者：Zheng, Guanchao;Che, Hanyu;Wu, Haiyan;Deng, Yuxiang;Guo, Mengmeng;Peng, Jixing;Geng, Qianqian;Tan, Zhijun;Tan, Zhijun;Tan, Zhijun
关键词：Paralytic shellfish toxins; Mytilus galloprovincialis; Gymnodinium catenatum; Epimerization conversion
-
Seasonal and inter-species variations in nutrient components and taste characteristics of farmed scallops from Northern China
作者：Lin, Yichen;Peng, Jixing;Zhao, Xinnan;Song, Dongru;Tan, Zhijun;Geng, Shichang;Tan, Zhijun
关键词：Farmed scallops; Seasonal variations; Interspecies difference; Nutrient and flavor composition; Quality comprehensive assessment
-
Fatty acids and lipids in sea cucumber from the Rongcheng Sanggou Bay, China: Variation characteristics and diversity profile of farming patterns and harvest seasons
作者：Zhao, Xinnan;Lin, Yichen;Huo, Shanqin;Wu, Haiyan;Guo, Mengmeng;Tan, Zhijun;Peng, Jixing;Tan, Zhijun
关键词：Apostichopus japonicus; Fatty acids; Lipidomic; Phospholipids; UPLC; HRMS
-
Comprehensive quality evaluation for oysters of geographical indication from Rushan in China: Characteristic profile of nutrition and flavor components
作者：Huo, Shanqin;Peng, Jixing;Zhao, Xinnan;Lin, Yichen;Wu, Haiyan;Zheng, Guanchao;Geng, Qianqian;Guo, Mengmeng;Tan, Zhijun;Huo, Shanqin;Tan, Zhijun
关键词：Crassostrea gigas; Nutrition quality; Flavor components; Comprehensive evaluation
-
Explainable Deep Learning to Predict Kelp Geographical Origin from Volatile Organic Compound Analysis
作者：Kang, Xuming;Tan, Zhijun;Zhao, Yanfang;Yao, Lin;Sheng, Xiaofeng;Guo, Yingying;Tan, Zhijun
关键词：kelp; volatile organic compounds; explainable deep learning; SHAP; geographical origin
-
Integration of bioaccumulations, chemical forms and gene expression responses to understand the transformation and detoxification of inorganic arsenic, cadmium and lead in the brown seaweed Sargassum fusiforme
作者：Zhao, Yanfang;Guo, Yingying;Kang, Xuming;Sheng, Xiaofeng;Tan, Zhijun;Wu, Jifa
关键词：Sargassum fusiforme; Toxic elements; Bioaccumulation; Detoxification; Chemical forms; Transcriptomic analysis
