The polysaccharides from the fruits of Lycium barbarum L. confer anti-diabetic effect by regulating gut microbiota and intestinal barrier
文献类型： 外文期刊
作者： Zhou, Wangting 1 ; Yang, Tingting 1 ; Xu, Weiqi 1 ; Huang, Yujie 1 ; Ran, Linwu 2 ; Yan, Yamei 3 ; Mi, Jia 3 ; Lu, Lu 3 ; Sun, Yi 1 ; Zeng, Xiaoxiong 1 ; Cao, Youlong 3 ;
作者机构： 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
2.Ningxia Med Univ, Lab Anim Ctr, Yinchuan 750004, Ningxia, Peoples R China
3.Ningxia Acad Agr & Forestry, Inst wolfberry Engn & Technol, Yinchuan 750004, Ningxia, Peoples R China
关键词： Lycium barbarum L; Polysaccharides; Gut microbiota; Barrier function; Hypoglycemic activity
期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：10.723； 五年影响因子：9.964 ）
ISSN： 0144-8617
年卷期： 2022 年 291 卷
页码：
收录情况： SCI
摘要： The antidiabetic effect and potential mechanisms of the polysaccharides from the fruits of Lycium barbarum L. (LBPs) by the mouse model of high-fat diet/streptozotocin-induced diabetes were investigated. Six-week oral administration of LBPs (200 mg/kg/day) resulted in improvement in the levels of fasting blood glucose (13.51% decrease) and glycated hemoglobin and beta-cell function in diabetic mice, and simultaneously induced a 3.3-fold increment in one taxon belonging to genus Allobaculum in gut bacterial community. The experiments of fecal microbiota transplantation and antibiotics treatment confirmed that the LBPs-mediated gut microbiota participated in the glycemic control of the diabetes management. Moreover, LBPs intervention guarded the intestinal barrier function via upregulating the expression of zonula occludens 1 both in vivo (analyzing the gut permeability in diabetic mice) and in vitro (using intestinal-like Caco-2/RAW264.7 cells co-culture inflammation model). Collectively, our study showed that LBPs could confer anti-diabetic effect through modifying gut microbiota and intestinal barrier.
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