The polysaccharides from the fruits of Lycium barbarum L. confer anti-diabetic effect by regulating gut microbiota and intestinal barrier
文献类型： 外文期刊
作者： Zhou, Wangting 1 ; Yang, Tingting 1 ; Xu, Weiqi 1 ; Huang, Yujie 1 ; Ran, Linwu 2 ; Yan, Yamei 3 ; Mi, Jia 3 ; Lu, Lu 3 ; Sun, Yi 1 ; Zeng, Xiaoxiong 1 ; Cao, Youlong 3 ;
作者机构： 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
2.Ningxia Med Univ, Lab Anim Ctr, Yinchuan 750004, Ningxia, Peoples R China
3.Ningxia Acad Agr & Forestry, Inst wolfberry Engn & Technol, Yinchuan 750004, Ningxia, Peoples R China
关键词： Lycium barbarum L; Polysaccharides; Gut microbiota; Barrier function; Hypoglycemic activity
期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：10.723； 五年影响因子：9.964 ）
ISSN： 0144-8617
年卷期： 2022 年 291 卷
页码：
收录情况： SCI
摘要： The antidiabetic effect and potential mechanisms of the polysaccharides from the fruits of Lycium barbarum L. (LBPs) by the mouse model of high-fat diet/streptozotocin-induced diabetes were investigated. Six-week oral administration of LBPs (200 mg/kg/day) resulted in improvement in the levels of fasting blood glucose (13.51% decrease) and glycated hemoglobin and beta-cell function in diabetic mice, and simultaneously induced a 3.3-fold increment in one taxon belonging to genus Allobaculum in gut bacterial community. The experiments of fecal microbiota transplantation and antibiotics treatment confirmed that the LBPs-mediated gut microbiota participated in the glycemic control of the diabetes management. Moreover, LBPs intervention guarded the intestinal barrier function via upregulating the expression of zonula occludens 1 both in vivo (analyzing the gut permeability in diabetic mice) and in vitro (using intestinal-like Caco-2/RAW264.7 cells co-culture inflammation model). Collectively, our study showed that LBPs could confer anti-diabetic effect through modifying gut microbiota and intestinal barrier.
- 相关文献
作者其他论文 更多>>
-
The effects of selenium on the translation efficiency of selenoproteins GPX1, GPX4, and TXNRD1 in oxLDL-induced EA.hy926 cells
作者：Lu, Jiaqi;Meng, Jing;Lang, Yanzhi;Ran, Linwu;Rehman, Abdul;Yan, Yamei
关键词：Selenium; Oxidized low density lipoprotein (oxLDL); Selenoprotein; Ribosome profiling; Translational efficiency
-
High-quality genome of black wolfberry (Lycium ruthenicum Murr.) provides insights into the genetics of anthocyanin biosynthesis regulation
作者：Xu, Yuhui;Luo, Qing;An, Wei;Zhao, Jian;Yin, Yue;He, Jun;Liang, Xiaojie;Wang, Yajun;Zhang, Xiyan;Shi, Zhigang;Duan, Linyuan;Qin, Xiaoya;Huang, Ting;Zhang, Bo;Wan, Ru;Li, Yanlong;Cao, Youlong;Zhao, Jianhua;Li, Haoxia;Shi, Tongwei;Chen, Yuchao;Guo, Shenghu;Tian, Weiwei;Zheng, Rui;Zheng, Rui;Liu, Hui;Shu, Sheng;Xiong, Aisheng
关键词：
-
Morphological, physiological, and transcriptomic insights into response the of Lycium barbarum L. ('Ningqi No.1') seedlings to low-nitrogen stress
作者：Wan, Ru;Hui, Tian;Yang, Libing;Wang, Xiao;Cao, Youlong;An, Wei;Zhang, Xiyan;Zhao, Jianhua;Wang, Yajun;Li, Yuekun;Shi, Zhigang;Wang, Hezhen
关键词：Low nitrogen; Wolfberry; RNA-Seq; Nitrogen metabolism; Phenylpropanoid metabolism
-
In vivo absorption and fecal excretion of polysaccharides from the fruits of Lycium barbarum L. in rats through fluorescence labeling
作者：Zhou, Wangting;Kan, Xuhui;Dong, Wei;Sun, Yi;Zeng, Xiaoxiong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong;Wang, Wei
关键词：Lycium barbarum polysaccharides; Fluorescence labeling; Absorption
-
Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism
作者：Li, Hui;Zhang, Meng;Tan, Tingting;Li, Shiying;Ran, Linwu;Li, Hui;Zhang, Meng;Tan, Tingting;Li, Shiying;Ran, Linwu;Mi, Jia;Lu, Lu;Yan, Yamei
关键词：Lycium ruthenicum Murray; female obesity; gut microbiota; bile acid metabolism
-
Petunidin-3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-(β-D-glucopyranoside), the main anthocyanin from the fruits of Lycium ruthenicum murray, enhances the lifespan of Caenorhabditis elegans by activating DAF-16 and improving the gut microbiota
作者：Zhang, Kangzhi;Zhu, Jiahao;Liu, Peiyun;Guo, Renpeng;Zeng, Xiaoxiong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong
关键词：Lycium ruthenicum murray; Caenorhabditis elegans; Lifespan; Antioxidant; Resistance; DAF-16; Intestinal microbiota
-
In vivo absorption and excretion in rats and in vitro digestion and fermentation by the human intestinal microbiota of 2-O-β-
d -glucopyranosyl-l -ascorbic acid from the fruits of Lycium barbarum L作者：Dong, Wei;Peng, Yujia;Xu, Weiqi;Zhou, Wangting;Zeng, Xiaoxiong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong
关键词：
