Binding of Fibronectin to SsPepO Facilitates the Development of Streptococcus suis Meningitis
文献类型： 外文期刊
作者： Liu, Feng 1 ; Li, Jinquan 1 ; Yan, Kang 1 ; Li, Huan 1 ; Sun, Chengfeng 1 ; Zhang, Shuo 5 ; Yuan, Fangyan 5 ; Wang, Xiang 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China
2.Huazhong Agr Univ, Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan, Hubei, Peoples R China
3.Huazhong Agr Univ, Coll Food Sci & Technol, State Key Lab Agr Microbiol, Wuhan, Hubei, Peoples R China
4.Huazhong Agr Univ, Minist Agr, Key Lab Dev Vet Diagnost Prod, Wuhan, Hubei, Peoples R China
5.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Hubei Key Lab Anim Embryo & Mol Breeding, Wuhan, Hubei, Peoples R China
关键词： fibronectin; meningitis; RGD peptide; SsPepO; Streptococcus suis
期刊名称：JOURNAL OF INFECTIOUS DISEASES （ 影响因子：5.226； 五年影响因子：5.802 ）
ISSN： 0022-1899
年卷期： 2018 年 217 卷 6 期
页码：
收录情况： SCI
摘要： Background. SsPepO is an important virulence in Streptococcus suis. Methods. In this study, we showed that SsPepO contributes to the human fibronectin-mediated adherence ability of S. suis to human brain microvascular endothelial cells. Results. The addition of an antifibronectin antibody or an arginine-glycine-aspartic acid peptide that blocks fibronectin binding to integrins significantly reduced adherence of the wild-type but not the SspepO mutant strain, indicating the importance of the SsPepO-fibronectin-integrin interaction for S. suis cellular adherence. Conclusions. By analyzing Evans blue extravasation in vivo, we showed that the interaction between SsPepO and human fibronectin significantly increased permeability of the blood-brain barrier. Furthermore, the SspepO mutant caused lower bacterial loads in the brain than wild-type S. suis in models of meningitis. These data demonstrate that SsPepO is a fibronectin-binding protein, which plays a contributing role in the development of S. suis meningitis.
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