文献类型： 外文期刊

作者： Dong, Li-Mei ¹ ; Huang, Li-Lan ² ; Dai, Hang ² ; Xu, Qiao-Lin ³ ; Ouyang, Jin-Kui ¹ ; Jia, Xu-Chao ⁴ ; Gu, Wen-Xiang ² ;

作者机构： 1.South China Agr Univ, Coll Forestry & Landscape Architecture, Guangdong Key Lab Innovat Dev & Utilizat Forest P, State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangzhou 510642, Guangdong, Peoples R China

2.South China Agr Univ, Coll Mat & Energy, Guangzhou 510642, Guangdong, Peoples R China

3.Guangdong Acad Forestry, Guangdong Prov Key Lab Biocontrol Forest Dis & Pe, Guangzhou 510520, Guangdong, Peoples R China

4.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangdong Key Lab Agr Prod Proc, Minist Agr,Key Lab Funct Foods, Guangzhou 510610, Guangdong, Peoples R China

关键词： Myoporum bontioides; methicillin-resistant Staphylococcus aureus (MRSA); sesquiterpene alkaloids

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2018 年 16 卷 11 期

页码：

收录情况： SCI

摘要： The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, which led to the isolation of two new sesquiterpene alkaloids (1 and 2) and six known furanosesquiterpenes (3-8). Their structures were elucidated on the basis of extensive analysis of their 1D, 2D NMR and mass spectroscopic data. These two new alkaloids (1 and 2) displayed potent anti-MRSA activity with MIC value of 6.25 g/mL. This is the first report of sesquiterpene alkaloids from the plants of Myoporum genus and their anti-MRSA activity.