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The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio)

文献类型： 外文期刊

作者： Chen, Xing 1 ; Fang, Mingliang 2 ; Chernick, Melissa 2 ; Wang, Feng 1 ; Yang, Jingfeng 1 ; Yu, Yongli 1 ; Zheng, Na 3 ; T 1 ;

作者机构： 1.Inner Mongolia Univ Nationalities, Collage Anim Sci & Technol, Inner Mongolia Key Lab Toxicant Monitoring & Toxi, Tongliao 028000, Inner Mongolia, Peoples R China

2.Duke Univ, Nicholas Sch Environm, Durham, NC 27705 USA

3.Chinese Acad Sci, Key Lab Wetland Ecol & Environm, Northeast Inst Geog & Agr Ecol, Changchun 130012, Jilin, Peoples R China

4.Rakuno Gakuen Univ, Sch Vet Med, Ebetsu, Hokkaido 0698501, Japan

5.Nanyang Technol Univ, Sch Civil & Environm Engn, 50 Nanyang Ave, Singapore 639798, Singapore

6.Chinese Acad Fishery Sci, Lab Marine Fisheries Sci & Food Prod Proc,Yellow, Qingdao Natl Lab Marine Sci & Technol,Key Lab Mar, Key Lab Maricultural Organism Dis Control,Minist, Qingdao 266071, Peoples R China

7.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China

关键词： Thiram; Zebrafish; Thyroid; Acute exposure; Notochord

期刊名称：GENERAL AND COMPARATIVE ENDOCRINOLOGY （ 影响因子：2.822； 五年影响因子：2.772 ）

ISSN： 0016-6480

年卷期： 2019 年 271 卷

页码：

收录情况： SCI

摘要： Thiram, a pesticide in the dithiocarbamate chemical family, is widely used to prevent fungal disease in seeds and crops. Its off-site movement to surface waters occurs and may place aquatic organisms at potential harm. Zebrafish embryos were used for investigation of acute (1 h) thiram exposure (0.001-10 mu M) at various developmental stages. Survival decreased at 1 mu M and 10 mu M and hatching was delayed at 0.1 mu M and 1 mu M. Notochord curvatures were seen at 0.1 and 1 mu M thiram when exposure was initiated at 2 and at 10 hpf. Similar notochord curvatures followed exposure to the known TPO inhibitor, methimazole (MMI). Changes were absent in embryos exposed at later stages, i.e., 12 hpf. In embryos exposed to 0.1 or 1 mu M at 10 hpf, levels of the thyroid enzyme, Deiodinase 3, increased by 12 hpf. Thyroid peroxide (TPO), important in T4 synthesis, decreased by 48 hpf in embryos exposed to 1 mu M at 10 hpf. Thiram toxicity was stage-dependent and early life stage exposure may be responsible for adverse effects seen later. These effects may be due to impacts on the thyroid via regulation of specific thyroid genes including TPO and Deiodinase 3.

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