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Identification of Differentially Expressed Genes and Pathways for Abdominal Fat Deposition in Ovariectomized and Sham-Operated Chickens

文献类型： 外文期刊

作者： Mu, Xiaopeng 1 ; Cui, Xiaoyan 2 ; Liu, Ranran 2 ; Li, Qinghe 2 ; Zheng, Maiqing 2 ; Zhao, Guiping 2 ; Ge, Changrong 5 ; W 1 ;

作者机构： 1.Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu Campus, Chengdu 611130, Sichuan, Peoples R China

2.Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China

3.State Key Lab Anim Nutr, Beijing 100193, Peoples R China

4.Minist Agr, Key Lab Anim Nutr & Feed Sci South China,Guangdon, Guangdong Acad Agr Sci,Guangdong Publ Lab Anim Br, Inst Anim Sci,State Key Lab Livestock & Poultry B, Guangzhou 510640, Guangdong, Peoples R China

5.Yunnan Agr Univ, Yunnan Prov Key Lab Anim Nutr & Feed, Kunming 650201, Yunnan, Peoples R China

关键词： chicken; abdominal fat; steroid biosynthesis; gene expression profiling; differentially expressed genes; glycerolipid metabolism

期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）

ISSN： 2073-4425

年卷期： 2019 年 10 卷 2 期

页码：

收录情况： SCI

摘要： Ovariectomy results in improved meat quality (growth rate, tenderness, and flavor) of broilers. However, some negative effects increased (abdominal fat (AF) deposition, low feed conversion, etc.) have also been reported. In this study, the gene expression profiles of AF tissue in ovariectomized and sham-operated chickens were determined to identify differentially expressed genes (DEGs) and pathways to explore the molecular mechanisms underlying AF accumulation. Comparing the ovariectomized group and the sham-operated group, the abdominal fat weight (AFW) and abdominal fat percentage (AFP) were increased significantly (p < 0.05) at 14 and 19 weeks after ovariectomy. According to the gene expression profiling analysis, 108 DEGs of fat metabolism were screened from 1461 DEGs. Among them, ABCA1, ABCACA, LPL, CREB1, PNPLA2, which are involved in glycerolipid-or steroid-associated biological processes, and the hormone receptor genes, ESR1 and PRLR, were down-regulated significantly in the ovariectomized group compared to the sham-operated group (p < 0.05). Conversely, CETP, DGAT2, DHCR24, HSD17B7 and MSMO1, were significantly up-regulated (p < 0.05) after ovariectomy. Based on the DEGs, the glycerolipid metabolism, steroid biosynthesis, and other signaling pathways (MAPK, TGF-beta, and adhesion pathways, etc.) were enriched, which may also contribute to the regulation of AF deposition. Our data suggest that AF deposition was significantly increased in ovariectomized chickens by the down-regulation of the decomposition genes of glycerolipid metabolism, which inhibits AF degradation, and the up-regulation of steroid biosynthesis genes, which increases fat accumulation. These findings provide new insights into the molecular mechanisms of fat deposition in the ovariectomized chickens.

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