Effect of Chronic Exposure to Methomyl on Tissue Damage and Apoptosis in Testis of Tilapia (Oreochromis niloticus) and Recovery Pattern
文献类型: 外文期刊
作者: Meng, Shun Long 1 ; Liu, Tao 2 ; Chen, Xi 1 ; Qiu, Li Ping 1 ; Hu, Geng Dong 1 ; Song, Chao 1 ; Fan, LiMin 1 ; Zheng, Yao 1 ;
作者机构: 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, 9 East Shanshui Rd, Wuxi 214081, Jiangsu, Peoples R China
2.Nanjing Agr Univ, Wuxi Fishery Coll, Wuxi 214081, Peoples R China
关键词: Methomyl; Apoptosis rate; Apoptosis enzyme; Tissue structure; Recovery pattern
期刊名称:BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY ( 影响因子:2.151; 五年影响因子:2.129 )
ISSN: 0007-4861
年卷期: 2019 年 102 卷 3 期
页码:
收录情况: SCI
摘要: Tilapia were exposed to 0, 0.2, 2, 20, 200 mu g/L methomyl for 30days, and then transferred to methomyl-free water for 18days. Caspase-8 in serum, apoptosis rate, microstructure and ultra-microstructure of testis were checked after methomyl exposure and at 18days after transferring to methomyl-free water. There were no significant changes in Caspase-8 activity, apoptosis rate, and tissue structure in testis exposed to 0.2 and 2 mu g/L compared with control. However, when tilapia exposed to 20 and 200 mu g/L, the Caspase-8 activity and apoptosis rate were induced significantly, and tissue damage happened compared with the control. Thus it would appear 2 mu g/L methomyl might be considered as the no observed adverse effect level. Recovery data showed that the effects produced by lower concentration of 20 mu g/L were reversible but not at the higher 200 mu g/L concentration.
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