Anti- asthmatic activity of alkaloid compounds from Pericarpium Citri Reticulatae ( Citrus reticulata ` Chachi')
文献类型： 外文期刊
作者： Fu, Manqin 1 ; Zou, Bo 1 ; An, Kejing 1 ; Yu, Yuanshan 1 ; Tang, Daobang 1 ; Wu, Jijun 1 ; Xu, Yujuan 1 ; Ti, Huihui 2 ;
作者机构： 1.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Key Lab Funct Foods, Minist Agr,Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Guangdong, Peoples R China
2.Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China
3.Guangzhou Med Univ, Sch Pharmaceut Sci, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：5.396； 五年影响因子：5.534 ）
ISSN： 2042-6496
年卷期： 2019 年 10 卷 2 期
页码：
收录情况： SCI
摘要： Pericarpium Citri Reticulatae (PCR, Citrus reticulata Chachi', Guangchenpi in Chinese) is one of the most famous Chinese citrus herbal medicines. The in vivo anti-asthmatic activity of Chachi' PCR was investigated using a histamine-induced experimental asthma model in Guinea pigs. Two alkaloid-type compounds, synephrine and stachydrine, were analyzed and identified in the Chachi' PCR alkaloid fraction. The alkaloid fraction and synephrine protected Guinea pigs against histamine-induced experimental asthma in a dose-dependent manner. The respective application of high, middle, and low doses of the Chachi' PCR alkaloid fraction significantly increased specific airway resistance by 284%, 328%, and 355%, and decreased dynamic compliance by 57%, 67%, and 75%. A similar change was observed for synephrine. The expression of eosinophils in bronchoalveolar lavage fluid (BALF) and serum IgE, IL-4, and IL-5 levels in histamine-induced experimental asthmatic Guinea pigs were significantly downregulated by the Chachi' PCR alkaloid fraction and synephrine compared to the control group, whereas stachydrine did not impart a statistically significant effect on the expression of tested inflammatory cells (leucocytes, eosinophils, neutrophils, and lymphocytes), immunoglobulin (IgE), or cytokines (IL-4 and IL-5). Pathological changes in lung tissues in each treatment group included the infiltration of inflammatory cells around the bronchia.
- 相关文献
作者其他论文 更多>>
-
Oxidation and nitrosation in Cantonese sausage during processing and storage-The impact of adding Prunus mume polyphenol
作者：Cheng, Jingrong;Chen, Peiyu;Liu, Xueming;Tang, Daobang;Yang, Huaigu;Chen, Peiyu;Zhu, Mingjun;Zhu, Mingjun
关键词：Cantonese sausage; Prunus mume polyphenols; Texture; Oxidation stability; Nitrite; N-nitrosamine
-
The effect of structural changes on the activity of peroxidase with different initial state under high-pressure freezing
作者：Liang, Zhanhong;Yu, Yuanshan;Zou, Bo;Fu, Manqin;Hu, Tenggen;Xu, Yujuan;Cheng, Lina;Liang, Zhanhong;Yin, Xiaomeng;Wang, Jin
关键词：High-pressure freezing; Peroxidase; Physical state; Structure; Activity; Molecular docking
-
Effects of the Species and Growth Stage on the Antioxidant and Antifungal Capacities, Polyphenol Contents, and Volatile Profiles of Bamboo Leaves
作者：Shen, Hui;Wang, Yan;Shi, Pingping;Li, Hong;Yang, Fang;Yu, Lijuan;Li, Hong;Chen, Yanan;Luo, Haibo;Hu, Tenggen;Yu, Yuanshan;Wang, Jinxiang
关键词：antifungal capacity; antioxidant capacity; bamboo leaf; genotype; volatile profile
-
Identification and structural characterization of key prebiotic fraction of soluble dietary fiber from grapefruit peel sponge layer and its regulation effect on gut microbiota
作者：Du, Xiaoyi;Chen, Jiajia;Hu, Tenggen;Xu, Yujuan;Wu, Jijun;Peng, Jian;Cheng, Lina;Yu, Yuanshan;Li, Lu
关键词：Grapefruit peel sponge layer; Key prebiotic fraction; Structure
-
Effect of liquid nitrogen spray quick-freezing technology on the quality of bamboo shoots, Dendrocalamus brandisii from Yunnan Province, China
作者：Fan, Zhenmei;Hu, Tenggen;Xu, Yujuan;Wu, Jijun;Yu, Yuanshan;Shen, Hui;Yu, Lijuan;Shi, Pingping;Fan, Zhenmei;Song, Xianliang
关键词：Freezing; Amino acid; Water state; Microstructure
-
Pomelo (Citrus grandis (L.) Osbeck) sponge layers as a potential source of soluble dietary fiiber: Evaluation of its physicochemical, structural and functional properties
作者：Chen, Xiaowei;Chen, Jiajia;Peng, Jian;Yu, Yuanshan;Wu, Jijun;Wen, Jing;Xu, Yujuan;Li, Lu;Kang, Zhiying;Wang, Yanhui
关键词：Functional property; Physicochemical characteristics; Pomelo sponge layers; Soluble dietary fiber; Structure
-
The quality of beef-soybean paste and the relationship between microbial composition and flavor changes during fermentation
作者：Zou, Jinhao;Xiao, Zeyuan;Wang, Xuping;Yang, Huaigu;Cheng, Jingrong;Liu, Xueming;Tang, Daobang
关键词：Fermentation; Compound seasoning; Flavor analysis; Microbial composition
