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Anti- asthmatic activity of alkaloid compounds from Pericarpium Citri Reticulatae ( Citrus reticulata ` Chachi')

文献类型： 外文期刊

作者： Fu, Manqin 1 ; Zou, Bo 1 ; An, Kejing 1 ; Yu, Yuanshan 1 ; Tang, Daobang 1 ; Wu, Jijun 1 ; Xu, Yujuan 1 ; Ti, Huihui 2 ;

作者机构： 1.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Key Lab Funct Foods, Minist Agr,Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Guangdong, Peoples R China

2.Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China

3.Guangzhou Med Univ, Sch Pharmaceut Sci, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China

期刊名称：FOOD & FUNCTION （ 影响因子：5.396； 五年影响因子：5.534 ）

ISSN： 2042-6496

年卷期： 2019 年 10 卷 2 期

页码：

收录情况： SCI

摘要： Pericarpium Citri Reticulatae (PCR, Citrus reticulata Chachi', Guangchenpi in Chinese) is one of the most famous Chinese citrus herbal medicines. The in vivo anti-asthmatic activity of Chachi' PCR was investigated using a histamine-induced experimental asthma model in Guinea pigs. Two alkaloid-type compounds, synephrine and stachydrine, were analyzed and identified in the Chachi' PCR alkaloid fraction. The alkaloid fraction and synephrine protected Guinea pigs against histamine-induced experimental asthma in a dose-dependent manner. The respective application of high, middle, and low doses of the Chachi' PCR alkaloid fraction significantly increased specific airway resistance by 284%, 328%, and 355%, and decreased dynamic compliance by 57%, 67%, and 75%. A similar change was observed for synephrine. The expression of eosinophils in bronchoalveolar lavage fluid (BALF) and serum IgE, IL-4, and IL-5 levels in histamine-induced experimental asthmatic Guinea pigs were significantly downregulated by the Chachi' PCR alkaloid fraction and synephrine compared to the control group, whereas stachydrine did not impart a statistically significant effect on the expression of tested inflammatory cells (leucocytes, eosinophils, neutrophils, and lymphocytes), immunoglobulin (IgE), or cytokines (IL-4 and IL-5). Pathological changes in lung tissues in each treatment group included the infiltration of inflammatory cells around the bronchia.

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