Effects of sanshoamides and capsaicinoids on plasma and liver lipid metabolism in hyperlipidemic rats
文献类型： 外文期刊
作者： Chen, Zhaojun 1 ; Liu, Yongxiang 1 ; Wang, Hui 1 ; Chen, Zhongai 1 ; Liu, Jia 1 ; Liu, Hui 1 ;
作者机构： 1.Guizhou Acad Agr Sci, Potato Inst Guizhou Prov, Guiyang 550000, Guizhou, Peoples R China
关键词： Capsaicinoid; Cholesterol metabolism; Hyperlipidemic rat; Sanshoamide
期刊名称：FOOD SCIENCE AND BIOTECHNOLOGY （ 影响因子：2.391； 五年影响因子：2.108 ）
ISSN： 1226-7708
年卷期： 2019 年 28 卷 2 期
页码：
收录情况： SCI
摘要： The objective of this study was to determine the effects of sanshoamides and capsaiciniods on plasma and liver lipid levels and the mRNA expression levels of key receptors involved in cholesterol metabolism in hyperlipidemic rats. A total of 56 three-week-old female Sprague-Dawley rats were assigned to 7 treatment groups based on initial body weight (n=8 rats per group). With certain combinations of sanshoamides and capsaicinoids significantly increased food intake, reduced lipid levels in blood and liver, improved histological characteristics of a fatty liver, down regulated mRNA expression levels of cholesterol 7-alpha-hydroxylase (CYP7A1), 3-hydroxyl-3-methylglutary CoA (HMG-CoA) and Farnesoid X Receptor (FXR) in liver and apical sodium-dependent bile acid transporter, Ileal Bile Acid Binding Protein and FXR in the ileum in hyperlipidemic rats. These results indicated that dietary supplementation with sanshoamides and capsaicinoids reduced blood lipid levels and improved cholesterol metabolism in hyperlipidemic rats.
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