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New Acylglycosides Flavones from Fuzhuan Brick Tea and Simulation Analysis of Their Bioactive Effects

文献类型： 外文期刊

作者： Lu, Ying 1 ; He, Yingjie 1 ; Zhu, Shihao 1 ; Zhong, Xiaohong 2 ; Chen, Dong 3 ; Liu, Zhonghua 1 ;

作者机构： 1.Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Changsha 410128, Hunan, Peoples R China

2.Hunan Agr Univ, Hort & Landscape Coll, Changsha 410128, Hunan, Peoples R China

3.Guangdong Acad Agr Sci, Drinkable Plant Res Inst, Tea Res Ctr, Guangzhou 510000, Guangdong, Peoples R China

关键词： Fuzhuan brick tea; acylglycosides flavones; camelliquercetisides; camellikaempferosides; molecular docking simulation

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2019 年 20 卷 3 期

页码：

收录情况： SCI

摘要： Four novel acylglycosides flavones (AGFs) including two quercetin acylglycosides and two kaempferol acylglycosides were isolated from Fuzhuan brick tea (FBT) as follows: quercetin 3-O-[-l-rhamnopyranosyl (13)] [2-O''-(E)-p-coumaroyl] [-d-glucopyranosyl (13)--l-rhamnopyranosyl (16)]--d-galactoside was named as camelliquercetiside E (1), quercetin 3-O-[-l-rhamnopyranosyl (13)] [2-O''-(E)-p-coumaroyl] [-l-rhamnopyranosyl (16)]--d-galactoside was named as camelliquercetiside F (2), kaempferol 3-O-[-l-arabinopyranosyl (13)] [2-O''-(E)-p-coumaroyl] [-d-glucopyranosyl (13)--l-rhamnopyranosyl (16)]--d-glucoside was named as camellikaempferoside D (3), kaempferol 3-O-[-l-arabinopyranosyl (13)] [2-O''-(E)-p-coumaroyl] [-l-rhamnopyranosyl (16)]--d-glucoside was named as camellikaempferoside E (4). Chemical structures of AGFs were identified by time-of-flight mass (TOF-MS) and NMR spectrometers (H-1 NMR, C-13 NMR, H-1-H-1 COSY, HMBC and HSQC), and the MS2 fragmentation pathway of AGFs was further investigated. The inhibitory abilities of AGFs and their proposed metabolites on -glucosidase and HMG-CoA reductase were analyzed by molecular docking simulation, and the results suggested that inhibitory activities of AGFs were significantly affected by acyl structure, number of glycosyl and conformation, and part of them had strong inhibitory activities on -glucosidase and HMG-CoA reductase, suggesting that AGFs and their metabolites might be important ingredients that participate in the regulation of hypoglycemic and hypolipidemic effects. The results provided new AGFs and research directions for the practical study of FBT health functions in future.

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