文献类型： 外文期刊
作者： Ren, Yi 1 ; Chao, Ling-Hui 1 ; Sun, Jing 1 ; Chen, Xiao-Nan 1 ; Yao, Hui-Na 1 ; Zhu, Zhi-Xiang 1 ; Dong, Dan 2 ; Liu, Tin 1 ;
作者机构： 1.Beijing Univ Chinese Med, Sch Chinese Materia Med, Modern Res Ctr Tradit Chinese Med, Beijing, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Inst Plant & Environm Protect, Beijing, Peoples R China
关键词： Penicillium oxalicum; polyketide; penicilloxalone; anti-neuroinflammatory activity
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）
ISSN： 1478-6419
年卷期： 2019 年 33 卷 3 期
页码：
收录情况： SCI
摘要： Two new polyketides, penicilloxalones A (1) and B (2), together with 13 known compounds (3-15), were isolated from the ethyl acetate extract of the solid substrate fermentation cultures of the fungus Penicillium oxalicum MHZ153. The structures of the isolates were determined by spectroscopic analysis and comparison of their spectroscopic and physicochemical data with the literature values. Compounds 7 and 11 showed inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 values of 0.9 +/- 0.2 mu M and 87.9 +/- 0.7 mu M, respectively. [GRAPHICS] .
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