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High prevalence of CTX-M belonging to ST410 and ST889 among ESBL producing E. coli isolates from waterfowl birds in China's tropical island, Hainan

文献类型： 外文期刊

作者： Yang, Hong 1 ; Rehman, Mujeeb Ur 1 ; Zhang, Shaqiu 1 ; Yang, Jing 1 ; Li, Yinqi 1 ; Gao, Jinhai 1 ; Gu, Lihong 4 ; Wang, 1 ;

作者机构： 1.Sichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Chengdu 611130, Sichuan, Peoples R China

2.Sichuan Agr Univ, Inst Prevent Vet Med, Chengdu 611130, Sichuan, Peoples R China

3.Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China

4.Hainan Acad Agr Sci, Inst Anim Sci & Vet, Haikou 571100, Hainan, Peoples R China

关键词： CTX-M; ESBL; Escherichia coli; MLST

期刊名称：ACTA TROPICA （ 影响因子：3.112； 五年影响因子：3.002 ）

ISSN： 0001-706X

年卷期： 2019 年 194 卷

页码：

收录情况： SCI

摘要： The epidemiology and genetic characteristics of extended-spectrum beta-lactamase (ESBL)-producing Escherichia colt (E. coli) have been widely studied in human and veterinary settings. ESBL-producing E. colt are generally reported in pigs, poultry, and dairy farm animals. Here, we report on the prevalence and genetic characteristics of beta-lactamase producing E. coli isolated from waterfowl birds in Hainan, China. After phenotypic confirmation, genes encoding bla(CTX-M), bla(SHV) and bla(TEM) were detected by polymerase chain reaction (PCR). The isolates were assigned to different phylogenetic groups, and multi-locus sequence typing (MLST). Taken as a whole, 289 (92.9%) out of 311 E. coli isolates from waterfowl birds were confirmed as ESBL phenotypes by double-disk synergy testing. Subsequent PCR analysis revealed that bla(CTX-M) was the predominant ESBL gene identified in 146 (46.9%) isolates, followed by the combination of bla(CTX-M) and bla(TEM) in 70 (22.5%) isolates. The majority of these positive isolates were assigned to phylogroup B2 (46.2%) followed by phylogroup A (43.6%). In addition, MLST assigned representative ESBL positive isolates (n = 40) to 18 STs, and ST410 (ST23cplx) was the most prevalent population (22.5%). The high prevalence of CTX-M and STs frequently associating with E. colt infections should be of concern as it poses threats to animal and public health. To the best of our knowledge, this is the first comprehensive study to report on the occurrence of ESBL producing E. coli from waterfowl birds in China.

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