Structural characterization and antitumor effects of chitosan oligosaccharides against orthotopic liver tumor via NF-kappa B signaling pathway
文献类型： 外文期刊
作者： Zou, Pan 1 ; Yuan, Shoujun 3 ; Yang, Xin 1 ; Guo, Yongze 4 ; Li, Linna 3 ; Xu, Chengwang 3 ; Zhai, Xingchen 1 ; Wang, Jin 1 ;
作者机构： 1.Harbin Inst Technol, Sch Chem & Chem Engn, Dept Food Sci & Engn, 92 West Dazhi St, Harbin 150090, Heilongjiang, Peoples R China
2.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Key Lab Agroprod Qual & Safety, 12 Zhongguancun South St, Beijing 100081, Peoples R China
3.Beijing Inst Radiat Med, Dept Pharmacol & Toxicol, 27 Taiping Rd, Beijing 100850, Peoples R China
4.Tianjin Acad Agr Sci, Tianjin Inst Agr Qual Stand & Testing Technol, Tianjin 300381, Peoples R China
关键词：
Chitosan oligosaccharides; Structural features; Macrophage; Immunoregulation; Orthotopic liver tumor; NF-kappa B signaling pathway
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）
ISSN： 1756-4646
年卷期： 2019 年 57 卷
页码：
收录情况： SCI
摘要：
Increasing studies have reported the antitumor effects of chitosan oligosaccharides (COS) against multiple cancer, including S180, colon tumor, etc. Here, the structural characters of COS were identified and its inhibitory effects against orthotopic liver tumor and immunoregulation effects were also studied. Degree of polymerization (DP) of COS is 2-6, degree of deacetylation (DD) is 98.38 +/- 1.34%. COS is positive charged with zeta potential at 11.27 +/- 1.56 mV, with diameter at about 100 nm. COS is protective to S180-bearing mouse, activates macrophage Ana-1, and promotes M1 polarization. The antitumor effects of COS against LM3 and HepG2 orthotopic liver tumor in vivo were measured combined with bioimaging system. The mRNA differential analysis of LM3 cell and HepG2 hallmarks alterations indicated that COS inhibits hepatoma via NF-kappa B pathway, which regulates PI3K/Akt, p38 MAPK, p53 and mitochondria-apoptotic signaling pathways. This study suggests that COS can be developed into an excellent antitumor candidate for liver tumor.
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