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Integrating miRNA and mRNA expression profiles in plasma of laying hens associated with heat stress

文献类型： 外文期刊

作者： Zhu, Lihui 1 ; Liao, Rongrong 1 ; Wu, Ning 3 ; Zhu, Gensheng 2 ; Tu, Yinyin 2 ; Yang, Changsuo 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, 2901 Beidi Rd, Shanghai 201106, Peoples R China

2.Natl Poultry Res Ctr Engn & Technol, Shanghai 201106, Peoples R China

3.Shanghai Haifeng Dafeng Poultry CO LTD, Bright Food Grp CO LTD, Shanghai 200085, Peoples R China

关键词： miRNA and mRNA; Regulatory mechanism; Laying hens; High temperature

期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.316； 五年影响因子：2.357 ）

ISSN： 0301-4851

年卷期： 2019 年 46 卷 3 期

页码：

收录情况： SCI

摘要： High temperature is one of the most common environmental stressors plaguing animal husbandry worldwide. Little is known about the regulatory roles of miRNAs in response to heat stress in laying hens. To systematically identify heat stress-responsive miRNAs and their targets in laying hens, the differential expression of miRNAs and mRNAs was compared under heat stress and normal temperature. We identified 16 miRNAs and 502 genes that were significantly changed in heat-stressed laying hens. By comparing the differentially expressed genes (DEGs) and the putative targets of the altered miRNAs based on bioinformatics prediction, 82 coordinated genes were identified. Gene ontology classification analyses of the 82 putative target genes showed that the biological category cellular response to stress' was prominently annotated. Notably, the response-related gene autophagy-related protein 9A was most likely controlled by the upregulated miRNAs gga-miR-92-5p, gga-miR-1618-5p, gga-miR-1737, and gga-miR-6557 in response to heat stress. Analysis of DEGs also revealed an increase in lipid metabolism in heat-stressed laying hens. Some of these genes were negatively correlated with the altered miRNAs, suggesting that they are potential targets of the miRNAs. Taken together, our results advance our understanding of the regulatory mechanism of heat-stress-induced injury in laying hens, specifically with regard to miRNAs.

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