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Rumen-derived lipopolysaccharide induced ruminal epithelium barrier damage in goats fed a high-concentrate diet

文献类型： 外文期刊

作者： Zhang, Kai 1 ; Meng, Meijuan 1 ; Gao, Lipeng 1 ; Tu, Yuanlu 1 ; Bai, Yunfeng 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Circular Agr Res Ctr, Nanjing, Jiangsu, Peoples R China

2.Minist Agr, Key Lab Crop & Livestock Integrated Farming, Nanjing, Jiangsu, Peoples R China

关键词： Goat; Subacute rumen acidosis; Lipopolysaccharide; Rumen epithelium; Tight junction proteins

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN： 0882-4010

年卷期： 2019 年 131 卷

页码：

收录情况： SCI

摘要： This study aimed to investigate the mechanism of lipopolysaccharide (LPS) released in the rumen on epithelium barrier function of goats fed a HC diet. Twelve Boer goats were randomly divided into two groups: low-concentrate(LC) diet and high-concentrate(HC) diet treatment. We found that the pH of rumen fluid in the HC group was lower than in the LC group (P < 0.05). The mRNA and protein expression levels of p38 mitogen-activated protein kinase (MAPK), extracellular regulated protein kinases (ERK), and c-Jun N-terminal kinase (JNK) in the rumen epithelium were lower in the LC group than the HC group (P < 0.05). Gene expression and protein levels of the tight junction proteins claudin-1, claudin-4, occludin, and Zona occludin-1 were all greater in the LC group than the HC group (P < 0.05). Staining of claudin-1, occludin and ZO-1 was became irregular. In conclusion, high concentrate diet feeding can impair rumen epithelium function and decrease tight junction protein expression through MAPK signaling pathway.

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