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Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28

文献类型： 外文期刊

作者： Lu, Yongzhong 1 ; Qiu, Qian 1 ; Li, Chen 2 ; Cheng, Linyue 1 ; Liu, Jie 1 ;

作者机构： 1.Qingdao Univ Sci & Technol, Shandong Prov Key Lab Biochem Engn, 53 Zhengzhou Rd, Qingdao 266042, Shandong, Peoples R China

2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, 106 Nanjing Rd, Qingdao 266071, Shandong, Peoples R China

关键词： Envelope protein; Inhibitory peptide; White spot syndrome virus; Shrimp

期刊名称：AQUACULTURE REPORTS （ 影响因子：3.216； 五年影响因子：3.812 ）

ISSN： 2352-5134

年卷期： 2019 年 14 卷

页码：

收录情况： SCI

摘要： Since effective chemotherapeutics or preventive measures are still unavailable, finding feasible approaches against white spot syndrome virus (WSSV) has always been the vital subject in shrimp farming field. Envelope proteins are the ideal targets for antiviral strategies development due to their indispensable roles in virus entry, and inhibitory peptides targeting them have been proved to be promising in blocking virus infection. In this study, the Wimley-White interfacial hydrophobicity scale (WWIHS) in combination with known structural data was applied to identify potential inhibitory peptides that targeted the envelope protein VP28 of WSSV. Results showed that two potential inhibitory peptides were identified, one of which exhibited not only obvious antiviral activity, but also broad-spectrum antimicrobial activity. The inhibitory peptide identified here can serve as a lead compound for anti-WSSV strategies development.

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