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Capability of polygonum cuspidatum extract in inhibiting AGEs and preventing diabetes

文献类型： 外文期刊

作者： Sheng, Zhanwu 1 ; Ai, Binling 1 ; Zheng, Lili 1 ; Zheng, Xiaoyan 1 ; Yang, Yang 1 ; Shen, Yixiao 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Haikou Expt Stn, Haikou, Hainan, Peoples R China

2.Louisiana State Univ, Agr Ctr, Sch Nutr & Food Sci, Baton Rouge, LA 70803 USA

关键词： advanced glycation end products (AGEs); diabetes; N epsilon-(Carboxymethyl)-L-lysine (CML); polygonum cuspidatum; protein glycation

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：2.863； 五年影响因子：3.141 ）

ISSN： 2048-7177

年卷期： 2019 年 7 卷 6 期

页码：

收录情况： SCI

摘要： Diabetes is a metabolic disorder disease associated with advanced glycation end products (AGEs) and protein glycation. The effect of polygonum cuspidatum extract (PE) on AGEs and N epsilon-(Carboxymethyl)-L-lysine formation, protein glycation, and diabetes was investigated. Six primary phenolics in a range of 12.36 mg/g for ellagic acid to 0.01 mg/g for piceid were determined in PE. In an intermediate-moisture-foods model, inhibition rate of PE was as high as 54.2% for AGEs and 78.9% for CML under aw 0.75. The protein glycation was also inhibited by PE. In a diabetic rat model, the levels of blood glucose, serum malondialdehyde, cholesterol, triglycerides, and low-density lipoproteins were effectively reduced by PE treatment. The antioxidation capacity (T-AOC) and superoxide dismutase (SOD) activity were also mediated by PE. Additionally, the activates of liver function-related enzymes including alkaline phosphatase (ALP), glutamate pyruvate transaminase (GPT), and glutamate oxaloacetate transaminase (GOT) in diabetic rat were improved by PE.

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