您好，欢迎访问中国热带农业科学院 机构知识库！
中国热带农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Structurally manipulated antioxidant peptides derived from wheat bran: Preparation and identification

文献类型： 外文期刊

作者： Zhuang, Min 1 ; Li, Jiaqing 2 ; Wang, Anqi 1 ; Li, Gaoheng 1 ; Ke, Sheng 1 ; Wang, Xuanyu 1 ; Ning, Ming 3 ; Sheng, Zhanwu 4 ; Wang, Bing 5 ; Zhou, Zhongkai 1 ;

作者机构： 1.Tianjin Univ Sci & Technol, Coll Food Sci & Engn, Tianjin 300457, Peoples R China

2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China

3.Shihezi Univ, Key Lab Proc & Qual Safety Control Characterist Ag, Minist Agr & Rural Affairs, Shihezi 832003, Peoples R China

4.Chinese Acad Trop Agr Sci, Haikou Expt Stn, Haikou 570101, Peoples R China

5.Charles Sturt Univ, Gulbali Inst Agr Water & Environm, Wagga Wagga, NSW 2678, Australia

关键词： Bioactive peptides; Antioxidant activity; Wheat Bran; Cellular model; Molecular docking; Keap1-Nrf2 interaction

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2024 年 442 卷

页码：

收录情况： SCI

摘要： Bioactive peptide's development is facing two challenges in terms of its lower yield and limited understanding of structurally orientated functionality. Therefore, peptides were prepared from wheat bran via a cocktail enzyme for achieving a higher level of hydrophobic amino acids than traditional method. The obtained peptides exhibited great antioxidant activities against H2O2-induced oxidative stress in HepG2 cells. Among them, 91 bioactive peptides were selected through the virtual screening, and their N -terminal and C -terminal contained many hydrophobic amino acids. Then the peptides with capacity to interact with Keap1 were identified by in silico simulation, because Keap1 acts as a sensor of redox insults. The results revealed that peptides DLDW and DLGL demonstrated the highest binding affinities, and a bridge was formed between Asp of DLGL and Arg415 of Klech domain, contributing to interfering Keap1-Nrf2 interaction. These findings implied a potential application of wheat bran peptides as nutraceuticals and health -promoting ingredients.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国热带农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台