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Digestive enzyme corona formed in simulated gastrointestinal tract and its impact on EGCG release from banana resistant starch nanoparticles

文献类型： 外文期刊

作者： Wang, Shenwan 1 ; Duan, Zhiying 2 ; Zheng, Lili 1 ; Yang, Yang 1 ; Zheng, Xiaoyan 1 ; Xiao, Dao 1 ; Ai, Binling 1 ; Wang, Mingfu 4 ; Sheng, Zhanwu 2 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Haikou Expt Stn, Haikou 571101, Peoples R China

3.Haikou Key Lab Banana Biol, Haikou 571101, Hainan, Peoples R China

4.Shenzhen Univ, Inst Adv Study, Shenzhen 518060, Guangdong, Peoples R China

关键词： Nanoparticles; Protein corona; Digestive enzymes; Starch nanoparticles; Drug release

期刊名称：FOOD HYDROCOLLOIDS （ 影响因子：11.0； 五年影响因子：11.3 ）

ISSN： 0268-005X

年卷期： 2024 年 146 卷

页码：

收录情况： SCI

摘要： The interaction of nanocarriers with gastrointestinal enzymes upon oral administration significantly impacts their performance as delivery systems. This work investigated the interaction between epigallocatechin gallate (EGCG) loaded into banana resistant starch nanoparticles (RSNPs) and digestive enzymes and its implications for EGCG release. The formation of a protein corona on EGCG-RSNPs in simulated gastrointestinal fluids was confirmed. The formation of this protein corona led to structural alterations in the pepsin and trypsin. Changes in enzyme conformation upon interaction with EGCG-RSNPs were elucidated using UV-Vis absorption and emission fluorescence spectroscopy. The activity of the enzymes remained largely unaffected despite these conformational changes. Additionally, the presence of the protein corona led to a slower, reduced release rate of EGCG. The results of this work will contribute to the growing knowledge of nanocarrier design for the delivery of bioactive compounds, paving the way for the development of innovative therapeutic strategies and functional foods with more excellent health benefits.

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