文献类型： 外文期刊

作者： Xiao, L. ¹ ; He, C. ¹ ; Luo, L. ¹ ; Yang, K. ² ; Yang, L. ¹ ; Xu, K. ¹ ; Zheng, Y. ¹ ; Gu, C. ² ; Huang, Q. ² ; Meng, H. ¹ ;

作者机构： 1.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai Key Lab Vet Biotechnol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

2.Shanghai Acad Agr Sci, Anim Husb & Vet Res Inst, 2901 Beidi Rd, Shanghai 201106, Peoples R China

关键词： dd-GBS; GWAS; pullorum disease; S; Pullorum

期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）

ISSN： 0268-9146

年卷期： 2019 年 50 卷 4 期

页码：

收录情况： SCI

摘要： Pullorum is a bacterial disease that threatens the modern poultry industry. Over the years, research on this topic has focused mainly on its epidemiology, whereas the hosts' genetic basis of infection is still vague. In order to identify chickens' genes associated with pullorum, we sequenced 300 New Pudong chicken by double digest genotyping-by-sequencing. We obtained 1 527 953 SNPs for a genome-wide association analysis, which identified 43 genome-wide significant markers. Most of the significant SNPs were in the interval of 57.7-59.0 Mb on chromosome 5. The gene set enrichment analysis suggests a potential manner for bacterial infection and remaining inside the host. This work provides basic data for the purification, prevention and treatment of pullorum disease.