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Marek's Disease Virus Infection Induced Mitochondria Changes in Chickens

文献类型： 外文期刊

作者： Chu, Qin 1 ; Ding, Yi 2 ; Cai, Wentao 2 ; Liu, Lei 2 ; Zhang, Huanmin 3 ; Song, Jiuzhou 2 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100094, Peoples R China

2.Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20740 USA

3.ARS, USDA, Avian Dis & Oncol Lab, E Lansing, MI 48823 USA

关键词： Marek's disease virus; mitochondrial DNA copy number; gene expression; immune response; T cell transformation

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2019 年 20 卷 13 期

页码：

收录情况： SCI

摘要： Mitochondria are crucial cellular organelles in eukaryotes and participate in many cell processes including immune response, growth development, and tumorigenesis. Marek's disease (MD), caused by an avian alpha-herpesvirus Marek's disease virus (MDV), is characterized with lymphomas and immunosuppression. In this research, we hypothesize that mitochondria may play roles in response to MDV infection. To test it, mitochondrial DNA (mtDNA) abundance and gene expression in immune organs were examined in two well-defined and highly inbred lines of chickens, the MD-susceptible line 7(2) and the MD-resistant line 6(3). We found that mitochondrial DNA contents decreased significantly at the transformation phase in spleen of the MD-susceptible line 7(2) birds in contrast to the MD-resistant line 6(3). The mtDNA-genes and the nucleus-genes relevant to mtDNA maintenance and transcription, however, were significantly up-regulated. Interestingly, we found that POLG2 might play a potential role that led to the imbalance of mtDNA copy number and gene expression alteration. MDV infection induced imbalance of mitochondrial contents and gene expression, demonstrating the indispensability of mitochondria in virus-induced cell transformation and subsequent lymphoma formation, such as MD development in chicken. This is the first report on relationship between virus infection and mitochondria in chicken, which provides important insights into the understanding on pathogenesis and tumorigenesis due to viral infection.

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