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Identification of piRNAs in the testes of Sunite and Small-tailed Han sheep

文献类型： 外文期刊

作者： He, Xiaolong 1 ; Li, Bei 2 ; Fu, Shaoyin 1 ; Wang, Biao 1 ; Qi, Yunxia 1 ; Da, Lai 1 ; Te, Rigele 1 ; Sun, Suzhen 1 ; Liu, Y 1 ;

作者机构： 1.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010031, Peoples R China

2.Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot 010018, Peoples R China

关键词： piRNAs; piRNA cluster; sheep; multiple births

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）

ISSN： 1049-5398

年卷期：

页码：

收录情况： SCI

摘要： P-element-induced wimpy testis-interacting RNAs (piRNAs) are small RNAs that are essential for mammalian spermatogenesis and testicular development. Comparative analyses of the molecular mechanisms of spermatogenesis among different organisms are therefore dependent on accurate piRNA characterizations. In this study, we identified piRNAs in the testes of two breeds of Mongolian sheep: the Sunite (SN), which has a low reproductive rate, and Small-tailed Han (STH), which has a high reproductive rate. A thorough understanding of the mechanisms underlying the differences in fecundity between the two breeds might provide insights for the improvement of fertility and reproductive success in these and other sheep breeds. We identified 835 piRNAs and 206 piRNA clusters across the two breeds. Of these, 29 putative piRNAs were expressed in the SN samples only, and 229 putative piRNAs were expressed in the STH samples only. In addition, 206 piRNA clusters were upregulated in STH sheep as compared to the SN sheep. Functional pathway analysis indicated that the genes neighboring the predicted piRNAs were likely associated with spermatogenesis. piRNAs might thus be linked to male fecundity in sheep. Our results increase knowledge of the association between piRNAs and male fertility.

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