Transcriptome analysis of juvenile genetically improved farmed tilapia (Oreochromis niloticus) livers by dietary resveratrol supplementation
文献类型： 外文期刊
作者： Zheng, Yao 1 ; Hu, Gengdong 1 ; Wu, Wei 1 ; Zhao, Zhixiang 2 ; Meng, Shunlong 1 ; Fan, Limin 1 ; Song, Chao 1 ; Qiu, Lipi 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Lab Qual & Safety Risk Assessment Aquat Prod Envi, Fishery Ecoevironm Monitoring Ctr Lower Reaches Y, Minist Agr,Freshwater Fisheries Res Ctr, Wuxi 214081, Jiangsu, Peoples R China
2.Nanjing Agr Univ, Wuxi Fishery Coll, Wuxi 214081, Jiangsu, Peoples R China
3.Minist Agr, Key Lab Control Qual & Safety Aquat Prod, Beijing, Peoples R China
关键词： Resveratrol; GIFT; RNA sequencing; Immune response; Chinese medical herbs
期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：3.228； 五年影响因子：3.289 ）
ISSN： 1532-0456
年卷期： 2019 年 223 卷
页码：
收录情况： SCI
摘要： Here we used RNA-Seq to explore the transcriptomic response and specific involvement of hepatic mRNA of juvenile Oreochromis niloticus (GIFT) as a result of dietary resveratrol supplementation (0.05 g/kg RES). More than 24,513,018 clean reads were reference genome guided assembly into 23,417 unigenes. 12,596 unigenes (29.64%) were annotated to GO database. There were 5, 179 and 1526 genes significantly differentially expressed genes at 15, 30 and 45 d respectively, and 8 KEGG pathways were enriched associated with this immune response. Hyperemia and compressed hepatic sinusoid, fibrosis of liver cell and abnormal hepatic epidermal cell revealed by H&E and SEM analysis respectively. Genes related with cytokine production (il12rb2, scfr), immune system (ig8l, hlfl, cd226, prf1l), autophagy regulation (atg4b), foxo signaling (ccnb2), steroid hormone biosynthesis (cyp3a40), fatty acid metabolism (scd1), metabolism (cacna1b) have been significantly decreased, while genes associated with such pathways above (leap-2, prdx4, mb, homer1, mif, sat1, cytbc1_8) and the pathway of protein processing in endoplasmic reticulum (cne1, tram1) have been significantly increased. These findings suggested RES activated some immune and biological process-related genes to enhance GIFT's innate immunity. It also suggested high concentration addition or long-time administration may bring negative effect in tilapia liver.
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