文献类型： 外文期刊

作者： Teng, Xiangqi ¹ ; Zhang, Weiqian ³ ; Song, Yangyang ¹ ; Wang, Haibin ¹ ; Ge, Ming ¹ ; Zhang, Ruili ¹ ;

作者机构： 1.Northeast Agr Univ, Coll Vet Med, Harbin 150030, Heilongjiang, Peoples R China

2.Northeast Agr Univ, Dept Heilongjiang Common Anim Dis Prevent & Treat, Key Lab Prov Educ, Harbin 150030, Heilongjiang, Peoples R China

3.Chinese Acad Fishery Sci, Qual & Stand Res Ctr, Beijing 100141, Peoples R China

关键词： Ganoderma lucidum triterpenoids; Cadmium; Spleen; Antioxidant; Apoptosis

期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH （ 影响因子：4.223； 五年影响因子：4.306 ）

ISSN： 0944-1344

年卷期： 2019 年 26 卷 23 期

页码：

收录情况： SCI

摘要： Cadmium (Cd) is a heavy metal that poses a huge potential threat to human and animal health. Therefore, it is necessary to study its damage mechanism. In the present study, we have examined the protective effects of Ganoderma lucidum triterpenoids on oxidative stress and apoptosis in the spleen of chickens induced by Cd. One hundred and twenty healthy Hailan white chickens (7-day-old) were randomly divided into the following four groups: control group, Cd group, triterpenoid group, and Cd-triterpenoid group. The chickens were euthanized on the 20th, 40th, and 60th days, and the spleens were removed. Cd and malondialdehyde (MDA) content, antioxidant enzyme (superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)) activities, and inflammatory factor (tumor necrosis factor alpha (TNF-alpha) and interleukin (IL-1 beta and IL-6)) and apoptotic factor (caspase-3, BAX, and Bcl-2) expressions were detected. The results showed that Ganoderma lucidum triterpenoids could reduce the content of Cd and MDA; increase the antioxidant enzyme activities (SOD and GSH-Px); decrease the expression of inflammatory factors (TNF-alpha) and interleukin (IL-1 beta and IL-6); increase the expression of apoptotic factor (Bcl-2); and decrease the expression of apoptotic factors (caspase-3 and Bax). It showed that the triterpenoids of Ganoderma lucidum had significant protective effects on oxidative stress and apoptosis of chicken spleen, which provided a theoretical basis for further prevention and treatment of cadmium poisoning.