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Bioactive Compounds Isolated from Marine Bacterium Vibrio neocaledonicus and Their Enzyme Inhibitory Activities

文献类型： 外文期刊

作者： Gomez-Betancur, Isabel 1 ; Zhao, Jianping 3 ; Tan, Lin 1 ; Chen, Chang 4 ; Yu, Ge 1 ; Rey-Suarez, Paola 2 ; Preciado, 1 ;

作者机构： 1.CATAS, Haikou Expt Stn, Haikou 571101, Hainan, Peoples R China

2.Univ Antioquia, Fac Ciencias Farmaceut & Alimentarias, Programa Ofidismo Escorpionismo, Medellin 1226, Colombia

3.Univ Mississippi, Sch Pharm, Natl Ctr Natl Prod Res, University, MS 38677 USA

4.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China

关键词： Vibrio neocaledonicus; acetylcholinesterase (AChE); alphaglucosidase (AG); xanthine oxidase (XO); indole; bioactive compounds; snake venom

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2019 年 17 卷 7 期

页码：

收录情况： SCI

摘要： Marine organisms are recognized as a source of compounds with interesting biological activities. Vibrio neocaledonicus has been reported on for its high effectiveness against corrosion in metals but it has been little studied for its chemical and biological activities. In this study, four compounds were isolated from V. neocaledonicus: indole (1); 1H-indole-3-carboxaldehyde (2); 4-hydroxybenzaldehyde (3) and Cyclo (-Pro-Tyr) (4); using a bioassay-guided method, since in a previous study it was found that the ethyl acetate extract was active on the enzymes acetylcholinesterase (AChE), alpha-glucosidase (AG) and xanthine oxidase (XO). The inhibitory activities of the three compounds against AChE, AG and XO was also evaluated. In addition, the enzymatic inhibitory activity of indole to the toxins from the venom of Bothrops asper was tested. Results showed that indole exhibited strong inhibitory activity to AG (IC50 = 18.65 +/- 1.1 mu M), to AChE, and XO (51.3% and 44.3% at 50 mu g/mL, respectively). 1H-indole-3-carboxaldehyde displayed strong activity to XO (IC50 = 13.36 +/- 0.39 mu M). 4-hydroxybenzaldehyde showed moderate activity to XO (50.75% at 50 mu g/mL) and weak activity to AChE (25.7% at 50 mu g/mL). Furthermore, indole showed a significant in vitro inhibition to the coagulant effect induced by 1.0 mu g of venom. The findings were supported by molecular docking. This is the first comprehensive report on the chemistry of V. neocaledonicus and the bioactivity of its metabolites.

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