您好，欢迎访问浙江省农业科学院 机构知识库！
浙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Multi-omics analysis reveals expression complexity and functional diversity of mouse kinome

文献类型： 外文期刊

作者： Huang, Xin 1 ; Li, Ling 3 ; Zhou, Suiping 4 ; Kong, Dehui 3 ; Luo, Jie 5 ; Lu, Lu 6 ; Xu, Hai-Ming 1 ; Wang, Xusheng 3 ;

作者机构： 1.Zhejiang Univ, Coll Agr & Biotechnol, Inst Crop Sci, Hangzhou 310058, Peoples R China

2.Zhejiang Univ, Coll Agr & Biotechnol, Inst Bioinformat, Hangzhou 310058, Peoples R China

3.Univ North Dakota, Dept Biol, Grand Forks, ND 58202 USA

4.St Jude Childrens Res Hosp, Ctr Prote & Metabol, 332 N Lauderdale St, Memphis, TN 38105 USA

5.Zhejiang Acad Agr Sci, Cent Lab, Hangzhou, Peoples R China

6.Univ Tennessee, Ctr Hlth Sci, Dept Genet Genom & Informat, Memphis, TN 38163 USA

关键词： BXD mice; C57BL; 6J; DBA; 2J; kinase activity; kinome; mouse; omics; PheWAS; protein expression; protein kinase; proteome

期刊名称：PROTEOMICS （ 影响因子：5.393； 五年影响因子：4.274 ）

ISSN： 1615-9853

年卷期：

页码：

收录情况： SCI

摘要： Protein kinases are a crucial component of signaling pathways involved in a wide range of cellular responses, including growth, proliferation, differentiation, and migration. Systematic investigation of protein kinases is critical to better understand phosphorylation-mediated signaling pathways and may provide insights into the development of potential therapeutic drug targets. Here we perform a systems-level analysis of the mouse kinome by analyzing multi-omics data. We used bulk and single-cell transcriptomic data from the C57BL/6J mouse strain to define tissue- and cell-type-specific expression of protein kinases, followed by investigating variations in sequence and expression between C57BL/6J and DBA/2J strains. We then profiled a deep brain phosphoproteome from C57BL/6J and DBA/2J strains as well as their reciprocal hybrids to infer the activity of the mouse kinome. Finally, we performed phenome-wide association analysis using the BXD recombinant inbred (RI) mice (a cross between C57BL/6J and DBA/2J strains) to identify any associations between variants in protein kinases and phenotypes. Collectively, our study provides a comprehensive analysis of the mouse kinome by investigating genetic sequence variation, tissue-specific expression patterns, and associations with downstream phenotypes.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：浙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台