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Characterization and evaluation of an oral vaccine via nano-carrier for surface immunogenic protein (Sip) delivery against Streptococcus agalactiae infection

文献类型： 外文期刊

作者： Zhu, Chunhua 1 ; Zhang, Na 1 ; Jing, Dingding 1 ; Liu, Xiaodong 2 ; Zeng, Zhanzhuang 5 ; Wang, Jingjing 1 ; Xiao, Fangnan 1 ; Zhang, Hong 1 ; Chi, Hongshu 2 ; Wan, Chunhe 2 ; Lin, Pingdong 1 ; Gong, Hui 2 ; Wu, Yunkun 1 ;

作者机构： 1.Fujian Normal Univ, Prov Univ Key Lab Cellular Stress Response & Metab, Coll Life Sci, Fuzhou 350117, Peoples R China

2.Fujian Acad Agr Sci, Inst Biotechnol, Inst Anim Husb & Vet Med, Fuzhou 350013, Peoples R China

3.Fujian Normal Univ, Coll Life Sci, Fujian Key Lab Dev & Neural Biol, Fuzhou 350117, Peoples R China

4.Fujian Normal Univ, Key Lab Optoelect Sci & Technol Med, Minist Educ, Fuzhou 350117, Peoples R China

5.Freshwater Fisheries Res Inst Fujian, Fuzhou 350002, Peoples R China

关键词： Streptococcus agalactiae; Sip antigens; Delivery; Nanoparticles; Nile tilapia; Oral vaccine

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2023 年 235 卷

页码：

收录情况： SCI

摘要： Streptococcus agalactiae causes systemic disease in a variety of wild and farmed fish, resulting in high levels of morbidity and mortality, as well as serious economic losses to the Nile tilapia aquaculture industry. The development of economic and applicable oral vaccines is therefore urgently needed for the sustainable devel-opment of Nile tilapia aquaculture. In this study, mesoporous silica nanoparticles (MSNs) were fabricated using sol-gel synthesis technology, and the antigens of surface immunogenic protein (Sip) was loaded into MSNs to develop a nanovaccine MSNs-Sip@HP55. The results showed that the prepared nanovaccine exhibited pH -controlled release, which could survive in the simulated gastric environment (pH 1.5), and release antigens in the simulated intestinal environment at pH 7.4. The nanovaccine could induce innate and adaptive immune responses in Nile tilapia. When the challenge doses were 1.5 x 106, 1.18 x 106, and 0.88 x 106 CFU/mL, the relative protection rates in immunized Nile tilapia were 63.33 %, 64.23 %, and 76.31 %, respectively. Taken together, the nanovaccine exhibited a high antigen utilization rate and was easily administered orally via feeding, which could protect Nile tilapia against challenge with S. agalactiae in large-scale farms. Oral vaccine based on MSNs carriers is a potentially promising strategy for the development of fish vaccines.

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