Structural Characterization and Anti-Inflammatory Activity of Polysaccharides from Tremella fuciformis on Monosodium Urate-Stimulated RAW264.7 Macrophages
文献类型： 外文期刊
作者： Deng, Wei 1 ; Wu, Li 2 ; Xiao, Zheng 2 ; Li, Yibin 2 ; Zheng, Zhipeng 1 ; Chen, Shouhui 2 ;
作者机构： 1.Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
2.Fujian Acad Agr Sci, Inst Food Sci & Technol, Fuzhou 350003, Peoples R China
3.Natl Res & Dev Ctr Edible Fungus Proc Technol, Fuzhou 350003, Peoples R China
4.Minist Agr & Rural Affairs, Coconstruct Minist & Prov, Key Lab Subtrop Characterist Fruits Vegetables & E, Fuzhou 350003, Peoples R China
5.Fujian Key Lab Agr Prod Food Proc, Fuzhou 350003, Peoples R China
关键词： Tremella fuciformis; polysaccharides; transcriptomics; hypoxia inducible factor-1 signaling pathway; anti-inflammatory activity
期刊名称：FOODS （ 影响因子：5.2； 五年影响因子：5.5 ）
ISSN：
年卷期： 2023 年 12 卷 24 期
页码：
收录情况： SCI
摘要： The structural characteristics and anti-inflammatory activity of Tremella fuciformis polysaccharides (TFPs) were investigated. The study showed that TFPs were mainly composed of mannose, rhamnose, glucuronic acid, glucose, galactose, xylose, and fucose. TFPs significantly inhibited monosodium urate (MSU)-induced inflammation of RAW264.7 cells, as well as the secretion levels of TNF-alpha, IL-1 beta, and IL-18 cytokines. The concentrations of malondialdehyde and reactive oxygen species in RAW264.7 macrophages were reduced, but superoxide dismutase activity was increased. RNA-Seq technology was applied to explore the mechanisms of TFPs ameliorating MSU-induced inflammation of RAW264.7 macrophages. Results revealed that TFPs significantly reduce MSU-stimulated inflammatory damage in RAW 264.7 cells by inhibiting signaling pathways like the hypoxia inducible factor-1 (HIF-1) signaling pathway and erythroblastic oncogene B (ErbB) signaling pathway. This study provides a foundation for TFPs to be developed as novel anti-inflammatory drugs.
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