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MicroRNAs in Medicinal Plants

文献类型： 外文期刊

作者： Sun, Mingyang 1 ; Xu, Shiqiang 1 ; Mei, Yu 1 ; Li, Jingyu 1 ; Gu, Yan 1 ; Zhang, Wenting 1 ; Wang, Jihua 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Crops Res Inst, Guangzhou 510640, Peoples R China

2.Guangdong Acad Agr Sci, Guangdong Prov Key Lab Crop Genet Improvement, Guangzhou 510640, Peoples R China

3.Guangdong Prov Engn & Technol Res Ctr Conservat &, Guangzhou 510640, Peoples R China

关键词： medicinal plant; miRNA; synthesis pathway; biological function

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）

ISSN：

年卷期： 2022 年 23 卷 18 期

页码：

收录情况： SCI

摘要： Medicinal plant microRNAs (miRNAs) are an endogenous class of small RNA central to the posttranscriptional regulation of gene expression. Biosynthetic research has shown that the mature miRNAs in medicinal plants can be produced from either the standard messenger RNA splicing mechanism or the pre-ribosomal RNA splicing process. The medicinal plant miRNA function is separated into two levels: (1) the cross-kingdom level, which is the regulation of disease-related genes in animal cells by oral intake, and (2) the intra-kingdom level, which is the participation of metabolism, development, and stress adaptation in homologous or heterologous plants. Increasing research continues to enrich the biosynthesis and function of medicinal plant miRNAs. In this review, peer-reviewed papers on medicinal plant miRNAs published on the Web of Science were discussed, covering a total of 78 species. The feasibility of the emerging role of medicinal plant miRNAs in regulating animal gene function was critically evaluated. Staged progress in intra-kingdom miRNA research has only been found in a few medicinal plants, which may be mainly inhibited by their long growth cycle, high demand for growth environment, immature genetic transformation, and difficult RNA extraction. The present review clarifies the research significance, opportunities, and challenges of medicinal plant miRNAs in drug development and agricultural production. The discussion of the latest results furthers the understanding of medicinal plant miRNAs and helps the rational design of the corresponding miRNA/target genes functional modules.

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