Enhanced in vivo antiviral activity against pseudorabies virus through transforming gallic acid into graphene quantum dots with stimulation of interferon-related immune responses
文献类型： 外文期刊
作者： Ye, Shiyi 1 ; Su, Fei 1 ; Li, Junxing 1 ; Yu, Bin 1 ; Xu, Lihua 1 ; Xiong, Tao 3 ; Shao, Kang 2 ; Yuan, Xiufang 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Peoples R China
2.Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China
3.Yangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
期刊名称：JOURNAL OF MATERIALS CHEMISTRY B （ 影响因子：7.0； 五年影响因子：6.5 ）
ISSN： 2050-750X
年卷期： 2023 年
页码：
收录情况： SCI
摘要： With the urgent need for antiviral agents, antiviral materials with high biocompatibility and antiviral effects have attracted a lot of attention. In this study, gallic acid, a natural polyphenolic compound, was transformed into biocompatible graphene quantum dots (GAGQDs) which exhibit enhanced antiviral activity against pseudo rabies virus (PRV). The as-prepared GAGQDs inhibit PRV proliferation with a 10(4)-fold reduction in viral titers. Investigation of the antiviral mechanism revealed that GAGQDs inhibit the adsorption, invasion and replication of PRV infection. Treatment with GAGQDs regulates the expression levels of interferon-related antiviral proteins, including mitochondrial antiviral-signaling protein (MAVS), signal transducer and activator of transcription 1 (STAT1) and 2 ',5 '-oligoadenylate synthetase 1 (OAS1), suggesting that GAGQDs can stimulate innate antiviral immune responses, resulting in enhanced antiviral effects. More importantly, GAGQD treatments alleviate clinical symptoms and reduce mortality in PRV-infected mice. Our results reveal the enhanced therapeutic effects of GAGQDs against PRV infection in vitro and in vivo, suggesting the potential of GAGQDs as a promising novel antiviral agent.
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