Carambolaside W Inhibited H1N1 Influenza Virus-Induced Oxidative Stress through STAT-3/BCL-XL Signaling Pathway
文献类型： 外文期刊
作者： Su, Jingyao 1 ; Lai, Jia 1 ; Li, Jiali 1 ; Liu, Xia 1 ; Chen, Haitian 1 ; Li, Chuqing 1 ; Zhu, Bing 1 ; Jia, Xuchao 2 ; Li, Yinghua 1 ;
作者机构： 1.Guangzhou Med Univ, Ctr Lab, Guangzhou Women & Childrens Med Ctr, 318 Renminzhong Rd, Guangzhou 510120, Peoples R China
2.Guangdong Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Funct Foods, Sericultural & Agrifood Res Inst,Guangdong Key Lab, Guangzhou 510610, Peoples R China
关键词： carambolaside W; oxidative stress; apoptosis
期刊名称：VIRUSES-BASEL （ 影响因子：4.7； 五年影响因子：4.8 ）
ISSN：
年卷期： 2023 年 15 卷 9 期
页码：
收录情况： SCI
摘要： The H1N1 influenza virus is highly infectious and pathogenic, and in recent years, it has often presented seasonal mass outbreaks of infection. People infected with H1N1 will develop a high fever and other respiratory infection symptoms. If not treated in time, complications such as pneumonia may occur. In this study, we focused on developing drugs that can effectively fight against with H1N1 virus. A flavonoid glycoside was extracted from the carambola, then characterized by HR-ESI-MS with the molecular formula C47H58O2, and named carambolaside W. The flavonoid glycosides were found to have good anti-H1N1 influenza virus effects. In this study, we verified that carambolaside W has low toxicity and can effectively inhibit influenza virus replication in vitro. H1N1 virus infection induces intracellular oxidative stress damage to accelerate disease progression. The results showed that carambolaside W effectively inhibited the oxidative stress caused by H1N1 infection. The Western blot assay also revealed that carambolaside W alters the expression of apoptosis-related proteins in vitro and exerts a good anti-H1N1 influenza virus effect. In summary, carambolaside W is a low-toxicity natural flavonoid that can effectively treat the H1N1 influenza virus as a potential anti-H1N1 virus agent.
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