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Reducing light exposure enhances the circadian rhythm of the biological clock through interactions with the gut microbiota

文献类型： 外文期刊

作者： Zhang, Yu 1 ; Li, Yong 1 ; Yuan, Yilin 1 ; Wang, Jun 1 ; Zhang, Shiyu 1 ; Zhu, Run 1 ; Wang, Yan 1 ; Wu, Yinbao 1 ; Liao, Xindi 1 ; Mi, Jiandui 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Peoples R China

2.Minist Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Guangzhou 510642, Peoples R China

3.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Peoples R China

4.Natl Local Joint Engn Res Ctr Livestock Breeding, Guangzhou 510642, Peoples R China

5.Lanzhou Univ, Coll Vet Med, State Key Lab Vet Etiol Biol, Lanzhou 730000, Peoples R China

6.South China Agr Univ, Coll Anim Sci, Wushan Rd, Guangzhou 510642, Peoples R China

关键词： Intermittent photoperiod; Laying hens; Circadian rhythm; Gut microbiota; Clock gene

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2023 年 858 卷

页码：

收录情况： SCI

摘要： Light mainly synergistically regulates the central biological clock system. In farming, long-term light exposure may induce metabolic disorders and increase the load on the liver in laying hens. In contrast, intermittent photoperiods can reduce light exposure and increase rest time to improve the health of laying hens. The circadian rhythms of gut microbes are essential for the health of the host. However, the circadian rhythms of gut microbes and how those microbes interact with the host under intermittent photoperiods are not clear. We used laying hens as a model to evaluate the circadian rhythms of gut microbes and biological clock genes under different intermittent photoperiods. Intermittent photoperiod 1 (IP1, 16 [3 h -L/1 h -D]: 8 D) enhanced the circadian rhythms of cBmal1, cBmal2, cCry1, and cCry2 in the hypothalamus and increased the expression of cClock, cBmal1, and cCry2 in the liver and seven clock genes in the cecal wall. The intermittent photoperiod also significantly altered the composition and metabolic function of the cecal microbiota via the melatonin pathway. The concentrations of short-chain fatty acids (SCFAs) and the abundance of SCFA-producing genera such as Odoribacter significantly increased under the IP1 treatment and might have further fed back into and strengthened the peripheral and central rhythms by activating the SCFA receptor gene pathway in cecal wall. These findings clarify the mediation mechanisms for the circadian rhythms of the central circadian clock and highlight the role of intermittent photoperiod-induced regulation of the interaction between the host clock and the cecal microbial community.

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