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Bacillus licheniformis reverses the environmental ceftriaxone sodium-induced gut microbial dysbiosis and intestinal inflammation in mice

文献类型： 外文期刊

作者： Zeng, Zhibo 1 ; Yue, Wen 1 ; Kined, Cermon 3 ; Wang, PengPeng 2 ; Liu, Ran 2 ; Liu, Jing 1 ; Chen, Xinzhu 1 ;

作者机构： 1.Inst Anim Husb & Vet Med, Fujian Acad Agr Sci, Fujian Key Lab Anim Genet & Breeding, Fuzhou 350013, Peoples R China

2.Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China

3.Swiss Fed Inst Technol, Inst Agr Sci, Univ Str 2, CH-8092 Zurich, Switzerland

关键词： Bacillus licheniformis; Antibiotic; Gut microbiota; 16S rRNA

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.8； 五年影响因子：6.9 ）

ISSN： 0147-6513

年卷期： 2023 年 257 卷

页码：

收录情况： SCI

摘要： Antibiotics used as a common clinical treatment have saved many lives. Widespread use of antibiotic therapy has been known to disrupt the balance of pathogenic bacteria, host-associated microorganisms and environment. However, our understanding of Bacillus licheniformis for health benefits and ability to restore the ceftriaxone sodium-induced gut microbial dysbiosis is severely limited. We used Caco-2 cell, H&E (hematoxylin-eosin staining), RT-PCR and 16S rRNA sequencing techniques to investigate the influence of Bacillus licheniformis on gut microbial dysbiosis and inflammation following ceftriaxone sodium treatment. The results showed that treatment of ceftriaxone sodium in 7 days suppressed the expression of Nf-kappa B pathway mRNA levels, which caused cytoplasmic vacuolization in intestinal tissues, afterward, the administration of Bacillus licheniformis could effectively restore intestinal morphology and inflammation levels. Moreover, the ceftriaxone sodium treatment entirely affected the intestinal microbial ecology, leading to a decrease in microbial abundance. Firmicutes, Proteobacteria, and Epsilonbacteraeota were the most predominant phyla in each of the four groups. Specifically, the MA group (ceftriaxone sodium treatment) resulted in a significant decrease in the relative abundance of 2 bacterial phyla and 20 bacterial genera compared to the administration of Bacillus licheniformis after ceftriaxone sodium treatment. The supplementation of Bacillus licheniformis could increase the growth of Firmicutes and Lactobacillus and encourage the construction of a more mature and stable microbiome. Furthermore, Bacillus licheniformis could restore the intestinal microbiome disorders and inflammation levels following ceftriaxone sodium treatment.

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