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Lactobacillus plantarum modulate gut microbiota and intestinal immunity in cyclophosphamide-treated mice model

文献类型： 外文期刊

作者： Zeng, Zhibo 1 ; Huang, Zonghao 1 ; Yue, Wen 1 ; Nawaz, Shah 2 ; Chen, Xinzhu 1 ; Liu, Jing 1 ;

作者机构： 1.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fujian Key Lab Anim Genet & Breeding, Fuzhou 350013, Peoples R China

2.Swiss Fed Inst Technol, Inst Agr Sci, Univ Str 2, CH-8092 Zurich, Switzerland

关键词： Lactobacillus plantarum; Cyclophosphamide; Gut microbiota; Immunology; Butyrate

期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：7.5； 五年影响因子：6.8 ）

ISSN： 0753-3322

年卷期： 2023 年 169 卷

页码：

收录情况： SCI

摘要： Gut microbiota (GM) contributes to the production of immune-regulatory molecules and cytokines. However, our understanding regarding intricate relationship between Lactobacillus plantarum and GM on regulation of immune function remained limited. To investigate the effect of Lactobacillus plantarum on an immunosuppressed mouse model, we employed cyclophosphamide treatment and conducted various analysis including H&E (hematoxylineosin staining), immunohistochemistry, 16S rRNA gene sequencing, and RT-PCR. Our results demonstrated that the administration of Lactobacillus plantarum had significant immunoenhancing effects in the immune-suppressed mice, as evidenced by the restoration of functional expression of specific immune markers in the spleen and an increase in the number of goblet cells in intestine (P < 0.05). Microbial taxonomic analysis revealed alterations in the gut microbiota composition, characterized by a decrease in the richness of Firmicutes and an increase in the proportion of Verrucomicrobia and Actinobacteria following cyclophosphamide treatment. Furthermore, cyclophosphamide treatment significantly suppressed the mRNA expression of inflammatory cytokines (P < 0.05), which were subsequently restored after administration of Lactobacillus plantarum. These observations provide valuable insights into the complex interplay between probiotics, gut microbiota, and immune system functioning.

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