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Dietary supplementation with anthocyanin attenuates lipopolysaccharide- induced intestinal damage through antioxidant effects in yellow-feathered broiler chicks

文献类型： 外文期刊

作者： Wang, Yibing 1 ; Ye, Jinling 1 ; Zhang, Sheng 1 ; Chen, Zhilong 1 ; Fan, Qiuli 1 ; Jiang, Shouqun 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Key Lab Anim Nutr & Feed Sci South China,Minist Ag, Guangzhou 510640, Peoples R China

关键词： anthocyanin; broiler; lipopolysaccharide; intestinal damage; antioxidant effect

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2023 年 102 卷 2 期

页码：

收录情况： SCI

摘要： This study investigated the protective effects of anthocyanin (AC) supplementation on lipo-polysaccharide (LPS)-challenged yellow-feathered broiler chicks. A total of 480 1-d female broiler chicks were randomly assigned to 4 treatment groups: basal diet (CON), basal diet + LPS-challenge (LPS), sup-plementation with 100 or 400 mg/kg AC + LPS-chal-lenge (AC100, AC400). On d 17 and d 19, birds in LPS, AC100 and AC400 received an intramuscular dose of LPS, while birds in CON received saline. The result showed that (1) LPS injection significantly decreased (P < 0.05) body weight on d 21 and average daily gain of broiler chicks from 1 to 21 days of age, and supplementation with 100 mg/kg AC increased (P < 0.05) those of LPS-challenged broilers. (2) There were no differences among the treatments (P > 0.05) in rela-tive weights of immune organs. (3) Supplementation with AC (AC100 and AC400) increased (P < 0.05) the jejunal villus height and villus height/crypt depth ratio (AC100) of LPS-challenged birds. Challenge with LPS decreased the relative expression of OCLN (Occludin), ZO-1, JAM2, and MUC2 in jejunal mucosa of broilers, and supplementation with AC offset the relative expression of ZO-1, JAM2 (AC100 and AC400), and OCLN (AC400) in LPS-injected broilers. (4) LPS-induced increase in the malondialdehyde (MDA) con-centration and decreases in activity of total superoxide dismutase (T-SOD), and expression of SOD1, CAT and GPX in jejunal mucosa, were attenuated by die-tary AC supplementation. In conclusion, in yellow -feathered broiler chicks, dietary supplementation with AC alleviated LPS-induced declined growth perfor-mance and mucosal damage of the intestine through antioxidant effects.

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