Stereoselective study on chiral fungicide metconazole in four kinds of fruits: Absolute configuration, SFC-MS/MS enantioseparation, degradation and risk assessment
文献类型： 外文期刊
作者： Diao, Ziyang 1 ; Di, Shanshan 2 ; Qi, Peipei 2 ; Liu, Zhenzhen 2 ; Wang, Zhiwei 2 ; Zhao, Huiyu 2 ; Wang, Meng 4 ; Zhang, Chenghui 1 ; Wang, Xinquan 2 ;
作者机构： 1.Hainan Univ, Coll Food Sci & Engn, 58 Renmin Ave, Haikou 570228, Hainan, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, key Lab Detect Pesticide Residues & Control Zhejia, Hangzhou 310021, Peoples R China
3.Agr Minist, Key Lab Pesticide Residue Detect, Hangzhou 310021, Peoples R China
4.Hainan Univ, Key Lab Trop Fruits & Vegetables Qual & Safety Sta, Haikou 570228, Peoples R China
5.Hainan Univ, Coll Plant Protect, Haikou 570228, Peoples R China
关键词： Chiral metconazole; Absolute configuration; SFC-MS/MS enantioseparation; Fruits; Stereoselective degradation
期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）
ISSN： 0308-8146
年卷期： 2024 年 438 卷
页码：
收录情况： SCI
摘要： Metconazole is a novel chiral fungicide with two chiral carbon atoms, but the research on its stereoselective behavior is limited. Therefore, the stereoselective behaviors of metconazole in four fruits, including grape, peach, pear and jujube, were summarized in this study. After determining the absolute configuration of metconazole stereoisomers, a chiral separation method through supercritical fluid chromatography/tandem triple quadrupole mass spectrometry was first developed, which combined an improved QuEChERS method obtained the recoveries of 71.6-113 % with RSD <= 19.8 %. The LOD and LOQ were 4.30-95.9 and 10.5-143.2 ng/kg, respectively. Different stereoselective and diastereoselective behaviors were observed in four fruits. Dietary risk assessments of rac-metconazole were performed in populations with different ages and genders. Both acute (RQa, 0.0124-0.140 %) and chronic (HQ, 0.0234-0.0794 %) intake risks were acceptable. The results of this study would contribute to more complete risk assessments of metconazole and provide data for chiral studies.
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