文献类型： 外文期刊

作者： Chen, Yi ¹ ; Hou, Guanmei ¹ ; Jing, Meidong ³ ; Teng, Huajing ¹ ; Liu, Quansheng ⁵ ; Yang, Xingen ⁶ ; Wang, Yong ⁷ ; Qu, ¹ ;

作者机构： 1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China

2.Univ Chinese Acad Sci, CAS Ctr Excellence Biot Interact, Beijing, Peoples R China

3.Nantong Univ, Sch Life Sci, Nantong, Peoples R China

4.Peking Univ, Dept Radiat Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing,Canc Hosp & Inst, Beijing, Peoples R China

5.Guangdong Acad Sci, Inst Zool, Guangdong Key Lab Anim Conservat & Resource Utili, Guangdong Publ Lab Wild Anim Conservat & Utilizat, Guangzhou, Peoples R China

6.Shanxi Acad Agr Sci, Inst Plant Protect, Shanxi Key Lab Integrated Pest Management Agr, Taiyuan, Peoples R China

7.Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Dongting Lake Stn Wetland Ecosyst Res, Changsha, Peoples R China

8.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Qinghai, Peoples R China

9.Hebei Agr Univ, Coll Plant Protect, Baoding, Peoples R China

10.Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China

关键词： colonization pattern; hypoxia adaptation; invasion mechanism; northward invasion; Rattus tanezumi; reference genome

期刊名称：MOLECULAR ECOLOGY （ 影响因子：6.185； 五年影响因子：6.801 ）

ISSN： 0962-1083

年卷期：

页码：

收录情况： SCI

摘要： The Asian house rat (AHR), Rattus tanezumi, has recently invaded the northern half of China. The AHR is a highly adaptive rat species that has also successfully conquered the Qinghai-Tibet Plateau (QTP) and replaced the brown rat (BR), R. norvegicus, at the edge of the QTP. Here, we assembled a draft genome of the AHR and explored the mechanisms of its northward invasion and the genetic basis underlying plateau adaptation in this species. Population genomic analyses revealed that the northwardly invasive AHRs consisted of two independent and genetically distinct populations which might result from multiple independent primary invasion events. One invasive population exhibited reduced genetic diversity and distinct population structure compared with its source population, while the other displayed preserved genetic polymorphisms and little genetic differentiation from its source population. Genes involved in G-protein coupled receptors and carbohydrate metabolism may contribute to the local adaptation of northern AHRs. In particular, RTN4 was identified as a key gene for AHRs in the QTP that favours adaptation to high-altitude hypoxia. Coincidently, the physiological performance and transcriptome profiles of hypoxia-exposed rats both showed better hypoxia adaptation in AHRs than in BRs that failed to colonize the heart of the QTP, which may have facilitated the replacement of the BR population by the invading AHRs at the edge of the QTP. This study provides profound insights into the multiple origins of the northwardly invasive AHR and the great tolerance to hypoxia in this species.